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Information Journal Paper

Title

Clofibrate for Non-Hemolytic Icterus in Term Newborns: Randomized-Controlled Trial, Iran

Pages

  00-00

Abstract

 Objectives: To compare the effects of a single dose of Clofibrate on the Serum Bilirubin level in full-term non-hemolytic icteric neonates when it is administered in addition to Phototherapy, and to evaluate its possible side effects. Methods: In a randomized-controlled clinical trial in 2016, 90 term icteric neonates were divided into groups of 30. One group took a single dose of 50 mg/kg while another group took a single dose of 100 mg/kg of Clofibrate. All neonates were under Phototherapy and were compared to a control group who took a placebo. Serum Bilirubin levels were measured at admission and then after 6, 12, 24, and 48 hours of treatment. Clofibrate’ s side effects were assessed by measuring hepatic enzymes (AST/ALT) and lipid profiles (TG/Chol) at admission and after 48 hours. Results: In neonates with Jaundice who were under Phototherapy, a single dose of 100 mg/kg of Clofibrate decreased the level of Serum Bilirubin more rapidly compared to the control group (t (58) =-2. 73, P = 0. 043), or even the group who took a single dose of 50 mg/kg Clofibrate (t (58) =-4. 261, P = 0. 000). A single dose of 50 mg/kg Clofibrate did not decrease the Serum Bilirubin levels more rapidly compared to the control group. Compared to the control group, in the group who took a single dose of 50 mg/kg Clofibrate, after 48 hours, a higher number of neonates showed an increase in serum triglyceride (30% versus 63%) and/or cholesterol levels (27% versus 57%). Conclusions: A single dose of 100 (not 50) mg/kg Clofibrate better decreased the Serum Bilirubin.

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    APA: Copy

    Gholami, Narges, Hosseini, Roshanak, & Naseh, Ali. (2019). Clofibrate for Non-Hemolytic Icterus in Term Newborns: Randomized-Controlled Trial, Iran. JOURNAL OF COMPREHENSIVE PEDIATRICS, 10(4), 00-00. SID. https://sid.ir/paper/760042/en

    Vancouver: Copy

    Gholami Narges, Hosseini Roshanak, Naseh Ali. Clofibrate for Non-Hemolytic Icterus in Term Newborns: Randomized-Controlled Trial, Iran. JOURNAL OF COMPREHENSIVE PEDIATRICS[Internet]. 2019;10(4):00-00. Available from: https://sid.ir/paper/760042/en

    IEEE: Copy

    Narges Gholami, Roshanak Hosseini, and Ali Naseh, “Clofibrate for Non-Hemolytic Icterus in Term Newborns: Randomized-Controlled Trial, Iran,” JOURNAL OF COMPREHENSIVE PEDIATRICS, vol. 10, no. 4, pp. 00–00, 2019, [Online]. Available: https://sid.ir/paper/760042/en

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