مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

183
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

278
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

Evaluation of Urinary Neutrophil Gelatinase-associated Lipocalin as a Biomarker in Pediatric Vesicoureteral Reflux Assessment

Pages

  373-379

Abstract

 Introduction. Defining a non-invasive marker to predict the risk of kidney damage is very helpful to manage vesicoureteral reflux (VUR) in children. This study aimed to investigate the predictive value of urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a non-invasive biomarker of reflux nephropathy in pediatric with primary VUR. Methods. This case-control study was performed on 63 children with primary VUR and 72 age-and sex-matched healthy children as controls. Urinary NGAL and creatinine levels were measured and compared between patients and control groups as well as among the subgroups of patients in terms of disease severity. Results. Among patients, 9 cases were diagnosed as mild, 35 as moderate, and 19 with a severe form of VUR. We observed higher but insignificant levels of uNGAL in patients versus healthy controls (P >. 05), in cases with severe form compared to mild and moderate forms of VUR (P >. 05) as well as in those patients with bilateral versus unilateral involvement (P >. 05). The mean ratios of uNGAL/uCr were significantly higher in patients group than controls (P <. 05) as well as in patients with severe form compared to moderate and mild forms of VUR (P <. 05 and P <. 05, respectively). Also, ROC analysis revealed the sensitivity of 61% and specificity of 53% for uNGAL/uCr ratio for prediction of VUR. Conclusion. Our findings indicate a potential predictive value of uNGAL/uCr ratio as a non-invasive biomarker for the management of VUR although, its clinical application has been challenging and needs to be confirmed by further investigations.

Cites

References

  • No record.

    • Cite

    APA: Copy

    Amiri, Rahimpour, FARADMAL, JAVAD, Rezaie, Bareza, SEDIGHI, IRAJ, Sanaei, Zahra, & SOLGI, GHASEM. (2020). Evaluation of Urinary Neutrophil Gelatinase-associated Lipocalin as a Biomarker in Pediatric Vesicoureteral Reflux Assessment. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 14(5), 373-379. SID. https://sid.ir/paper/760067/en

    Vancouver: Copy

    Amiri Rahimpour, FARADMAL JAVAD, Rezaie Bareza, SEDIGHI IRAJ, Sanaei Zahra, SOLGI GHASEM. Evaluation of Urinary Neutrophil Gelatinase-associated Lipocalin as a Biomarker in Pediatric Vesicoureteral Reflux Assessment. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2020;14(5):373-379. Available from: https://sid.ir/paper/760067/en

    IEEE: Copy

    Rahimpour Amiri, JAVAD FARADMAL, Bareza Rezaie, IRAJ SEDIGHI, Zahra Sanaei, and GHASEM SOLGI, “Evaluation of Urinary Neutrophil Gelatinase-associated Lipocalin as a Biomarker in Pediatric Vesicoureteral Reflux Assessment,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 14, no. 5, pp. 373–379, 2020, [Online]. Available: https://sid.ir/paper/760067/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button