Rosuvastatin Affects Tracheal Responsiveness, Bronchoalveolar Lavage Inflammatory Cells, and Oxidative Stress Markers in Hyperlipidemic and Asthmatic Rats

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SAADAT SAEIDEH; Mokhtari Zaer Amin; HADJZADEH MOSA AL REZA; HADJZADEH MOSA AL REZA; BOSKABADY MOHAMMAD HOSSEIN

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Journal Paper

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:6 Page(s): 624-638

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Title

Rosuvastatin Affects Tracheal Responsiveness, Bronchoalveolar Lavage Inflammatory Cells, and Oxidative Stress Markers in Hyperlipidemic and Asthmatic Rats

Author(s)

Keywords

Asthma

Hyperlipidemia

Oxidative stress

Rosuvastatin

Abstract

Statins provide greater protection than predicted from just cholesterol-lowering effects, which is possibly mediated by other pleiotropic actions. This study aimed to examine the possible interaction effect of Asthma on lipid profiles and evaluate the effect of Rosuvastatin treatment on Asthma. The animals were assigned into (1) control, (2) Asthmatic, (3) hyperlipidemic, (4) Asthmatic-hyperlipidemic, (5) Rosuvastatin (40 mg/kg/day intraperitoneally, for 3 weeks)-treated Asthmatic, (6) Rosuvastatin-treated hyperlipidemic and (7) Rosuvastatin-treated Asthmatic-hyperlipidemic groups. Tracheal responsiveness to methacholine and ovalbumin, total and differential WBC (white blood cell) counts, and Oxidative stress markers in bronchoalveolar lavage fluid (BALF) were evaluated. In the Asthmatic and Asthmatic-hyperlipidemic groups, tracheal responsiveness to ovalbumin, total WBC count, numbers of eosinophils, neutrophils, and monocytes were higher than the control group (p<0. 001). A left-ward shift in the concentration-response curves to methacholine, an increase in nitrite and malondialdehyde concentrations, and a decrease in total thiol content, superoxide dismutase and catalase activities were also observed in the Asthmatic and Asthmatic-hyperlipidemic groups compared to control group (p<0. 01 to p<0. 001). Beyond lipid-lowering effect in the treated hyperlipidemic and Asthmatic-hyperlipidemic groups, Rosuvastatin treatment decreased tracheal responsiveness to methacholine, reduced total WBC count, the numbers of eosinophils, neutrophils, and monocytes, as well as decreased malondialdehyde concentration, and increased total thiol content, superoxide dismutase and catalase activities in treated Asthmatic and Asthmatic-hyperlipidemic groups (p<0. 05 to p<0. 001). The improving effect of Rosuvastatin on Asthmatic and Asthmatic-hyperlipidemic animals was shown due to pleiotropic mechanisms including the effect on airway hyperresponsiveness, lung inflammation, and Oxidative stress.

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APA: Copy

SAADAT, SAEIDEH, Mokhtari Zaer, Amin, HADJZADEH, MOSA AL REZA, HADJZADEH, MOSA AL REZA, & BOSKABADY, MOHAMMAD HOSSEIN. (2019). Rosuvastatin Affects Tracheal Responsiveness, Bronchoalveolar Lavage Inflammatory Cells, and Oxidative Stress Markers in Hyperlipidemic and Asthmatic Rats. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(6), 624-638. SID. https://sid.ir/paper/760269/en

Vancouver: Copy

SAADAT SAEIDEH, Mokhtari Zaer Amin, HADJZADEH MOSA AL REZA, HADJZADEH MOSA AL REZA, BOSKABADY MOHAMMAD HOSSEIN. Rosuvastatin Affects Tracheal Responsiveness, Bronchoalveolar Lavage Inflammatory Cells, and Oxidative Stress Markers in Hyperlipidemic and Asthmatic Rats. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(6):624-638. Available from: https://sid.ir/paper/760269/en

IEEE: Copy

SAEIDEH SAADAT, Amin Mokhtari Zaer, MOSA AL REZA HADJZADEH, MOSA AL REZA HADJZADEH, and MOHAMMAD HOSSEIN BOSKABADY, “Rosuvastatin Affects Tracheal Responsiveness, Bronchoalveolar Lavage Inflammatory Cells, and Oxidative Stress Markers in Hyperlipidemic and Asthmatic Rats,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 6, pp. 624–638, 2019, [Online]. Available: https://sid.ir/paper/760269/en

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