مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

147
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

214
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The Effect of Curcumin in Prevention of Contrast Nephropathy Following Coronary Angiography or Angioplasty in CKD Patients

Pages

  304-309

Abstract

 Introduction. Contrast-induced nephropathy (CIN) is the most common cause of iatrogenic acute kidney injury, happens more commonly in patients with underlying kidney diseases. It has been shown that oxidative stress is the main mechanism of contrast nephropathy. curcumin is suggested as an herbal antioxidant agent, thus we decided to assess the effect of curcumin in preventing this complication in patients with underlying chronic kidney disease who need coronary angiography. Methods. We conducted double blind, placebo-controlled clinical trial in 60 moderate to severe CKD patients who underwent coronary angiography or angioplasty. Adjusted dose of Iodixanol was used as contrast agent in all of them. curcumin or placebo administered orally, 1. 5 g daily from 2 days before procedure to 3 days after it. CIN was defined by an increased serum creatinine ≥ 0. 3 mg/dL or an increase to ≥ 1. 5 times of the baseline within 48 hours after procedure. Results. CIN occurred in 12 (20%) of patients, 5 (16. 7%) in curcumin group and 7 (23. 3%) in placebo group (OR = 0. 56, 95% CI = 0. 18 to 2. 36; P >. 05). Serum Creatinine was increased after 72 hours of intervention from 1. 65 ± 0. 26 mg/dL to 1. 79 ± 0. 33 mg/dL in curcumin group and from 1. 61 ± 0. 23 mg/dL to 1. 86 ± 0. 35 in placebo group. No significant difference was seen between the mean increase of serum creatinine in two groups (difference of 0. 006 mg/dL, 95% CI =-0. 06 to 0. 08; P >. 05). Conclusion. Prophylactic oral curcumin could not show protective effects on CIN in high-risk patients who have undergone coronary procedures.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    HAMI, MARYAM, Bigdeli, Amir, KHAMENEH BAGHERI, RAMIN, RAJABI, OMID, SALEHI, MARYAM, & ZAHEDI AVVAL, FARNAZ. (2019). The Effect of Curcumin in Prevention of Contrast Nephropathy Following Coronary Angiography or Angioplasty in CKD Patients. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 13(5), 304-309. SID. https://sid.ir/paper/760501/en

    Vancouver: Copy

    HAMI MARYAM, Bigdeli Amir, KHAMENEH BAGHERI RAMIN, RAJABI OMID, SALEHI MARYAM, ZAHEDI AVVAL FARNAZ. The Effect of Curcumin in Prevention of Contrast Nephropathy Following Coronary Angiography or Angioplasty in CKD Patients. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2019;13(5):304-309. Available from: https://sid.ir/paper/760501/en

    IEEE: Copy

    MARYAM HAMI, Amir Bigdeli, RAMIN KHAMENEH BAGHERI, OMID RAJABI, MARYAM SALEHI, and FARNAZ ZAHEDI AVVAL, “The Effect of Curcumin in Prevention of Contrast Nephropathy Following Coronary Angiography or Angioplasty in CKD Patients,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 13, no. 5, pp. 304–309, 2019, [Online]. Available: https://sid.ir/paper/760501/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button