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Information Journal Paper

Title

Use of Topical 5-Fluorouracil for Keratocystic Odontogenic Tumors of Gorlin-Goltz Syndrome as a New Targeted Therapy: A Case Report and Review of Literature

Pages

  43-48

Keywords

Salicylic acid Drug Combination [Supplementary Concept] 

Abstract

 Background and Aim: Keratocystic Odontogenic Tumors (KOT) have a high rate of Recurrence, which is higher in patients diagnosed with Gorlin-Goltz syndrome (GGS). Adjunctive therapies, such as fixative chemical solutions, decrease the rate of Recurrence after enucleation and peripheral ostectomy but have high morbidity rates. Topical 5-fluorouracil (5-FU) has been suggested as a new therapy that provides a directed molecular approach to treatment. Case Presentation: This is a case report of GGS treated using topical 5-FU as an adjunctive material after enucleation and peripheral ostectomy. New bone formation sites were identified in the radiographic follow-up. The patient was followed up for 10 months regularly without any evidence of Recurrence. Conclusion: 5-FlU is an effective and novel targeted treatment for KOTs. Topical application of 5-FU, following enucleation and peripheral ostectomy, effectively treats syndromic KOTs, resulting in normal bony healing with no adverse local or systemic effects.

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    Cite

    APA: Copy

    Shiran, Hossein, Shafaei Fard, SH., HAKIMI, S., & Azari Pour Esfahani, A.. (2019). Use of Topical 5-Fluorouracil for Keratocystic Odontogenic Tumors of Gorlin-Goltz Syndrome as a New Targeted Therapy: A Case Report and Review of Literature. JOURNAL OF RESEARCH IN DENTAL AND MAXILLOFACIAL SCIENCES, 4(4), 43-48. SID. https://sid.ir/paper/760974/en

    Vancouver: Copy

    Shiran Hossein, Shafaei Fard SH., HAKIMI S., Azari Pour Esfahani A.. Use of Topical 5-Fluorouracil for Keratocystic Odontogenic Tumors of Gorlin-Goltz Syndrome as a New Targeted Therapy: A Case Report and Review of Literature. JOURNAL OF RESEARCH IN DENTAL AND MAXILLOFACIAL SCIENCES[Internet]. 2019;4(4):43-48. Available from: https://sid.ir/paper/760974/en

    IEEE: Copy

    Hossein Shiran, SH. Shafaei Fard, S. HAKIMI, and A. Azari Pour Esfahani, “Use of Topical 5-Fluorouracil for Keratocystic Odontogenic Tumors of Gorlin-Goltz Syndrome as a New Targeted Therapy: A Case Report and Review of Literature,” JOURNAL OF RESEARCH IN DENTAL AND MAXILLOFACIAL SCIENCES, vol. 4, no. 4, pp. 43–48, 2019, [Online]. Available: https://sid.ir/paper/760974/en

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