99mTc-MIBI SPECT/CT imaging contribution in the diagnosis of patients with hyperparathyroidism

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Nevena Manevska; SINISA STOJANOSKI; Bojana Stoilovska; Irena Sazdova

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2019 | Volume:27 | Issue:1 (SERIAL NUMBER 52) Page(s): 1-7

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Title

99mTc-MIBI SPECT/CT imaging contribution in the diagnosis of patients with hyperparathyroidism

Author(s)

Nevena Manevska | SINISA STOJANOSKI | Bojana Stoilovska | Irena Sazdova | Issue Writer Certificate

Keywords

Hyperparathyroidism

Parathyroid

SPECT/CT

99mTc-MIBI

Ultrasound

Abstract

Introduction: Parathyroidism/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HyperParathyroidism is presented with increased Parathyroid hormone (PTH) secretion due to hyperfunctioning of one or more of the four Parathyroid glands. Primary Parathyroidism/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HyperParathyroidism (p-HPT) can be due to Parathyroid adenoma, hyperplasia or carcinoma of the Parathyroid gland. Secondary Parathyroidism/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HyperParathyroidism (s-HPT) is usually a response to hypocalcaemia and consecutive hyperplasia of the glands. Our aim was to compare the efficacy of 99mTcmethoxyisobutylisonitrile (MIBI) SPECT/CT in identification of the location of the lesion(s) in cases of HPT by comparing these results with the findings of Ultrasound (US) and planar scintigraphy. Methods: Forty one consecutive patients (54± 17 age, 12 males and 29 females) with primary or secondary Parathyroidism/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HyperParathyroidism were included. All patients were examined by US and afterwards patients underwent conventional double-phase 99mTc-MIBI scintigraphy combined with neck SPECT/CT procedure. Planar images (early and delayed), US and SPECT/CT image sets were evaluated for adenoma localization at the neck and thorax. Regions of interest (ROIs), equal sized, were selected and compared, over the hyperfunctioning Parathyroid tissue (accumulated impulses-counts value) and over the contralateral lobe of the thyroid gland (control counts value). Results: The ultrasonography detected 24 positive findings. The late phase of planar scan detected 26 positive findings. SPECT/CT presented with bigger detection rate than late planar phase or US (75. 6%, 63. 4%, 61. 5%) and with higher sensitivity (100%, 83. 8%, 77. 4%), respectively. Conclusion: The SPECT/CT study seems reliable, sensitive and with added value in diagnosing Parathyroidism/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">HyperParathyroidism as a complementary method to planar scintigraphy. US as compatible method, should be performed prior the scintigraphy protocols.

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APA: Copy

Nevena, Manevska, SINISA, STOJANOSKI, Bojana, Stoilovska, & Irena, Sazdova. (2019). 99mTc-MIBI SPECT/CT imaging contribution in the diagnosis of patients with hyperparathyroidism. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 27(1 (SERIAL NUMBER 52)), 1-7. SID. https://sid.ir/paper/762108/en

Vancouver: Copy

Nevena Manevska, SINISA STOJANOSKI, Bojana Stoilovska, Irena Sazdova. 99mTc-MIBI SPECT/CT imaging contribution in the diagnosis of patients with hyperparathyroidism. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2019;27(1 (SERIAL NUMBER 52)):1-7. Available from: https://sid.ir/paper/762108/en

IEEE: Copy

Manevska Nevena, STOJANOSKI SINISA, Stoilovska Bojana, and Sazdova Irena, “99mTc-MIBI SPECT/CT imaging contribution in the diagnosis of patients with hyperparathyroidism,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 27, no. 1 (SERIAL NUMBER 52), pp. 1–7, 2019, [Online]. Available: https://sid.ir/paper/762108/en

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