Effect of Swimming Exercise to Cardiac PGC-1  and HIF-1  Gene Expression in Mice

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Sylviana Nova; Helja Niswan; Qolbi Hadaral Hudanul; Goenawan Hanna; Lesmana Ronny; A Syamsunarno Mas Rizky A; Agustina Hasrayati; Tiksnadi Badai Batara; Megantara Imam; Tarawan Vita Murniati; Setiawan Setiawan; HERNOWO BETHY; Supratman Unang; Purba Ambrosius

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Journal: Asian Journal of Sports Medicine Year:2018 | Volume:9 | Issue:4 Page(s): 0-0

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Title

Effect of Swimming Exercise to Cardiac PGC-1 and HIF-1 Gene Expression in Mice

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Keywords

Cardiac

Swimming

HIF-1

PGC-1

Hypoxia

Moderate Intensity

Abstract

Background: Hypoxia caused by exercise condition may alter PGC-1 and HIF-1 expression in Cardiac cells. Both factors are transcriptional factors which play a role in conserving energy during metabolic process. However, there is less information about the effects of long term Moderate Intensity exercise such as Swimming on PGC-1 and HIF-1 expression in Cardiac cells. Objectives: Aim of this study is to observe the effect of force Swimming exercise on the expression PGC-1 and HIF-1 gene expression in Cardiac muscle of mice. Methods: Male BALBc mice were divided into two groups (n = 10): control (C) and Swimming (ST). ST group was subjected to Moderate Intensity Swimming for 4 weeks, 30 minutes/day for 5 days. Hearts of animal models were preserved for Cardiac morphology study using HE staining, PGC-1 and HIF-1 mRNA expression study. Results: We observed that Cardiac PGC-1 expression in ST was significantly increased 1. 5 fold compared with control group (0. 64 vs 0. 44; CI = 95%,-0. 378-0. 019; P = 0. 035), but expression of HIF-1 was significantly decreased 0. 4 times lower than control group (0. 35 vs 0. 52; CI = 95%, 0. 27-0. 31; P = 0, 025). Conclusions: Taken together, ST group increased the expression of PGC-1 but decreased the expression of HIF-1 in mice Cardiac muscle in response to chronic Hypoxia condition.

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APA: Copy

Sylviana, Nova, Helja, Niswan, Qolbi, Hadaral Hudanul, Goenawan, Hanna, Lesmana, Ronny, A Syamsunarno, Mas Rizky A, Agustina, Hasrayati, Tiksnadi, Badai Batara, Megantara, Imam, Tarawan, Vita Murniati, Setiawan, Setiawan, HERNOWO, BETHY, Supratman, Unang, & Purba, Ambrosius. (2018). Effect of Swimming Exercise to Cardiac PGC-1 and HIF-1 Gene Expression in Mice. ASIAN JOURNAL OF SPORTS MEDICINE, 9(4), 0-0. SID. https://sid.ir/paper/762124/en

Vancouver: Copy

Sylviana Nova, Helja Niswan, Qolbi Hadaral Hudanul, Goenawan Hanna, Lesmana Ronny, A Syamsunarno Mas Rizky A, Agustina Hasrayati, Tiksnadi Badai Batara, Megantara Imam, Tarawan Vita Murniati, Setiawan Setiawan, HERNOWO BETHY, Supratman Unang, Purba Ambrosius. Effect of Swimming Exercise to Cardiac PGC-1 and HIF-1 Gene Expression in Mice. ASIAN JOURNAL OF SPORTS MEDICINE[Internet]. 2018;9(4):0-0. Available from: https://sid.ir/paper/762124/en

IEEE: Copy

Nova Sylviana, Niswan Helja, Hadaral Hudanul Qolbi, Hanna Goenawan, Ronny Lesmana, Mas Rizky A A Syamsunarno, Hasrayati Agustina, Badai Batara Tiksnadi, Imam Megantara, Vita Murniati Tarawan, Setiawan Setiawan, BETHY HERNOWO, Unang Supratman, and Ambrosius Purba, “Effect of Swimming Exercise to Cardiac PGC-1 and HIF-1 Gene Expression in Mice,” ASIAN JOURNAL OF SPORTS MEDICINE, vol. 9, no. 4, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/762124/en

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