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Information Journal Paper

Title

A Comparative Study in Influence of Isoflurane and Propofol on IL-1, IL-6, TNF-α Serum Levels after Craniotomy for Supratentorial Brain Tumors

Pages

  8-14

Abstract

 Background: The purpose of this randomized, single-center study was to prospectively investigate the impact of anesthetic techniques for Craniotomy on the release of cytokines (interleukin (IL)-1, IL-6, tumor necrosis factor factor-alpha (TNF-α )) and to determine whether intravenous anesthesia compared to inhalational anesthesia attenuates the inflammatory response. Methods and Materials: The study enrolled 60 patients undergoing Craniotomy, allocated into two equal groups to receive either Isoflurane (n=30) and Propofol (n=30). Non-invasive hemodynamic monitoring was used. Serum levels of IL-1, IL-6 and TNF-α were evaluated before and at the end of surgery and anesthesia. Results: Although there was a significant rise in serum level of inflammatory cytokine but compared with patients anaesthetized with Isoflurane, patients who received Propofol had significant lower levels of IL-1, IL-6 and TNF-a after surgery (p<0. 05). Conclusion: Patients who received Propofol had lower levels of IL-1, IL-6 and TNF-α after surgery. Our findings should incite future studies to prove a potential medically important anti-inflammatory role of Propofol in neuroanesthesia.

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    Cite

    APA: Copy

    SAFARI, FARHAD, SEZARI, PARISA, MOTTAGHI, KAMRAN, Torbat Isfahani, Bahareh, & NASHIBI, MASOUD. (2019). A Comparative Study in Influence of Isoflurane and Propofol on IL-1, IL-6, TNF-α Serum Levels after Craniotomy for Supratentorial Brain Tumors. JOURNAL OF CELLULAR AND MOLECULAR ANESTHESIA, 4(1), 8-14. SID. https://sid.ir/paper/762348/en

    Vancouver: Copy

    SAFARI FARHAD, SEZARI PARISA, MOTTAGHI KAMRAN, Torbat Isfahani Bahareh, NASHIBI MASOUD. A Comparative Study in Influence of Isoflurane and Propofol on IL-1, IL-6, TNF-α Serum Levels after Craniotomy for Supratentorial Brain Tumors. JOURNAL OF CELLULAR AND MOLECULAR ANESTHESIA[Internet]. 2019;4(1):8-14. Available from: https://sid.ir/paper/762348/en

    IEEE: Copy

    FARHAD SAFARI, PARISA SEZARI, KAMRAN MOTTAGHI, Bahareh Torbat Isfahani, and MASOUD NASHIBI, “A Comparative Study in Influence of Isoflurane and Propofol on IL-1, IL-6, TNF-α Serum Levels after Craniotomy for Supratentorial Brain Tumors,” JOURNAL OF CELLULAR AND MOLECULAR ANESTHESIA, vol. 4, no. 1, pp. 8–14, 2019, [Online]. Available: https://sid.ir/paper/762348/en

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