RELATIONSHIP BETWEEN VITAMIN D PLASMA LEVEL AND FOXP3 GENE EXPRESSION AMONG RHEUMATOID ARTHRITIS PATIENTS

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ZAFARI P.; MOSTAFAEI SH.; IRANSHAHI N.; JALILI C.; TAGHADOSI M.

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Journal Paper

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Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2018 | Volume:22 | Issue:6 Page(s): 40-48

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Title

RELATIONSHIP BETWEEN VITAMIN D PLASMA LEVEL AND FOXP3 GENE EXPRESSION AMONG RHEUMATOID ARTHRITIS PATIENTS

Author(s)

Keywords

VITAMIN DQ2

FOXP3Q2

RHEUMATOID ARTHRITISQ2

Abstract

Background and Aim: RHEUMATOID ARTHRITIS (RA) is an autoimmune disease. It seems that the function of regulatory T cells (Tregs) is compromised in RA. FOXP3 is a critical transcription factor of these cells. The aim of this study was to determine the relationship of VITAMIN D plasma level with FOXP3 gene expression in the patients with RA.Material and Methods: 18 untreated RA patients and 41 healthy people participated in this study. Plasma levels of VITAMIN D were measured by competitive ELISA method. FOXP3 gene expression was also determined by using realtime PCR technique.Results: The expression of FOXP3 gene was significantly lower in RA patients compared to that in the healthy controls (p<0.001).There was no significant relationship between VITAMIN D plasma levels with the rate of FOXP3 gene expression.Conclusion: We found low levels of VITAMIN D could not affect the expression of FOXP3 gene. It seems that VITAMIN D deficiency cannot be considered as an effective environmental factor in the pathogenesis of RA.

Cites

Evaluation of Beclin-1 and Atg5 genes expression levels in peripheral blood cells of patients with rheumatoid arthritis

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APA: Copy

ZAFARI, P., MOSTAFAEI, SH., IRANSHAHI, N., JALILI, C., & TAGHADOSI, M.. (2018). RELATIONSHIP BETWEEN VITAMIN D PLASMA LEVEL AND FOXP3 GENE EXPRESSION AMONG RHEUMATOID ARTHRITIS PATIENTS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 22(6 ), 40-48. SID. https://sid.ir/paper/76248/en

Vancouver: Copy

ZAFARI P., MOSTAFAEI SH., IRANSHAHI N., JALILI C., TAGHADOSI M.. RELATIONSHIP BETWEEN VITAMIN D PLASMA LEVEL AND FOXP3 GENE EXPRESSION AMONG RHEUMATOID ARTHRITIS PATIENTS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;22(6 ):40-48. Available from: https://sid.ir/paper/76248/en

IEEE: Copy

P. ZAFARI, SH. MOSTAFAEI, N. IRANSHAHI, C. JALILI, and M. TAGHADOSI, “RELATIONSHIP BETWEEN VITAMIN D PLASMA LEVEL AND FOXP3 GENE EXPRESSION AMONG RHEUMATOID ARTHRITIS PATIENTS,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 6 , pp. 40–48, 2018, [Online]. Available: https://sid.ir/paper/76248/en

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