EVALUATION OF MOLECULAR MECHANISMS RESISTANCE TO MACROLIDE BY S. PNEUMONIAE STRAINS ISOLATED FROM NEMAZEE AND SHAHID FAGHIHI HOSPITALS IN SHIRAZ

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARGAR M.; BAGHERNEJAD M.; GHORBANI DALINI S.; HASHEMIZADEH Z.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:16 | Issue:4 (SERIAL NUMBER 62) Page(s): 83-91

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,435

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF MOLECULAR MECHANISMS RESISTANCE TO MACROLIDE BY S. PNEUMONIAE STRAINS ISOLATED FROM NEMAZEE AND SHAHID FAGHIHI HOSPITALS IN SHIRAZ

Author(s)

KARGAR M. | BAGHERNEJAD M. | GHORBANI DALINI S. | HASHEMIZADEH Z. | Issue Writer Certificate

Keywords

S.PNEUMONIAEQ2

MACROLIDE RESISTANCEQ2

MEFAQ2

ERMBQ2

Abstract

Background and Aim: Macrolide StreptococcuS.PNEUMONIAE is generally mediated by two mechanisms: 23SrRNA methylation and efflux. The aim of this study was to assess the molecular mechanism of resistance in S.PNEUMONIAE strains isolated from intensive care units in Shiraz.Materials and Methods: This was a cross - sectional study.50 strains of S.PNEUMONIAE were obtained from the patients admitted to intensive care units (ICU) of Nemazee and Shahid-Faghihi Hospitals, from 2010 to 2011. Suspected colonies were identified by phenotypical and biochemical tests. Organisms were confirmed to be StreptococcuS.PNEUMONIAE on the basis of the presence of lytA gene by PCR method. Antibiotic resistance was evaluated according to Standard Clinical and Laboratory Standards Institute (CLSI). MACROLIDE RESISTANCE genes were identified by use of ERMB and MEFA specific primers. Using SPSS software, statistical analysis was performed by means of chi- square test.Results: Resistance to erythromycin, clarithromycin and azithromycin levofloxacin were 18%, 48% and 44% respectively. In this study, 25 strains (50%) had MEFA and 21 (42%) had ERMB genes. Erythromycin resistance had significant relationships with MEFA and ERMB genes.Conclusion: The results of our study showed that the predominant mechanism of MACROLIDE RESISTANCE was due to MEFA gene in this area. Increased MACROLIDE RESISTANCE calls for attention to the pattern of resistance in the therapeutic regimens.

Cites

No record.

References

No record.

Cite

APA: Copy

KARGAR, M., BAGHERNEJAD, M., GHORBANI DALINI, S., & HASHEMIZADEH, Z.. (2012). EVALUATION OF MOLECULAR MECHANISMS RESISTANCE TO MACROLIDE BY S. PNEUMONIAE STRAINS ISOLATED FROM NEMAZEE AND SHAHID FAGHIHI HOSPITALS IN SHIRAZ. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 16(4 (SERIAL NUMBER 62)), 83-91. SID. https://sid.ir/paper/76263/en

Vancouver: Copy

KARGAR M., BAGHERNEJAD M., GHORBANI DALINI S., HASHEMIZADEH Z.. EVALUATION OF MOLECULAR MECHANISMS RESISTANCE TO MACROLIDE BY S. PNEUMONIAE STRAINS ISOLATED FROM NEMAZEE AND SHAHID FAGHIHI HOSPITALS IN SHIRAZ. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;16(4 (SERIAL NUMBER 62)):83-91. Available from: https://sid.ir/paper/76263/en

IEEE: Copy

M. KARGAR, M. BAGHERNEJAD, S. GHORBANI DALINI, and Z. HASHEMIZADEH, “EVALUATION OF MOLECULAR MECHANISMS RESISTANCE TO MACROLIDE BY S. PNEUMONIAE STRAINS ISOLATED FROM NEMAZEE AND SHAHID FAGHIHI HOSPITALS IN SHIRAZ,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 4 (SERIAL NUMBER 62), pp. 83–91, 2012, [Online]. Available: https://sid.ir/paper/76263/en

Related Journal Papers