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Information Journal Paper

Title

Association Analysis of Monoamine Oxidase-A Gene Promoter Polymorphism (MAOA uVNTR) for Antisocial Behavior: Absence of the Counting Number Repeats in Central Iran

Pages

  0-0

Abstract

 Background: The MAOA Gene is located on the X chromosome (Xp11. 23). Several studies have established a VNTR (Variable Number Tandem Repeat) polymorphism in the upstream of the MAOA Gene transcriptional initiation region named uVNTR which is correlated with the risk of Antisocial Behavior. Objectives: This study aimed to investigate the association between MAOA genotypes and the risk of violent behavior in a cohort of violent and age-matched non-violent individuals. Methods: In the current case-control study, MAOAuVNTRwasgenotyped in a cohort of 88 violentand95 age-matched non-violent individuals. Individuals were genotyped for the MAOA uVNTR by performing PCR, gel electrophoresis, and sequencing. Furthermore, a chi-square test was performed using SPSS, and a p-value of less than 0. 05 was considered statistically significant. Results: We identified three MAOA uVNTR allelic variants: They were harboring 3. 5, 4. 5, and 5. 5 repeated sequences. Alleles with 2, 3, 4, 5, and 6 repeats were not observed in any of the two examined groups. Conclusions: We did not detect a statistically appreciable association between Antisocial Behavior and allele frequencies in the studied population in central Iran.

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    APA: Copy

    Khosravian, Maryam, NIKPOUR, PARVANEH, EMADI BAYGI, MODJTABA, SOLEIMANPOUR, ALI, & Moghadam, Fereidoun Yadollah. (2020). Association Analysis of Monoamine Oxidase-A Gene Promoter Polymorphism (MAOA uVNTR) for Antisocial Behavior: Absence of the Counting Number Repeats in Central Iran. ARCHIVES OF NEUROSCIENCE, 7(4), 0-0. SID. https://sid.ir/paper/762731/en

    Vancouver: Copy

    Khosravian Maryam, NIKPOUR PARVANEH, EMADI BAYGI MODJTABA, SOLEIMANPOUR ALI, Moghadam Fereidoun Yadollah. Association Analysis of Monoamine Oxidase-A Gene Promoter Polymorphism (MAOA uVNTR) for Antisocial Behavior: Absence of the Counting Number Repeats in Central Iran. ARCHIVES OF NEUROSCIENCE[Internet]. 2020;7(4):0-0. Available from: https://sid.ir/paper/762731/en

    IEEE: Copy

    Maryam Khosravian, PARVANEH NIKPOUR, MODJTABA EMADI BAYGI, ALI SOLEIMANPOUR, and Fereidoun Yadollah Moghadam, “Association Analysis of Monoamine Oxidase-A Gene Promoter Polymorphism (MAOA uVNTR) for Antisocial Behavior: Absence of the Counting Number Repeats in Central Iran,” ARCHIVES OF NEUROSCIENCE, vol. 7, no. 4, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/762731/en

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