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Information Journal Paper

Title

Direct comparison of 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in patients with prostate cancer

Pages

  1-7

Abstract

 Objective(s): 99mTc-PSMA SPECT/CT is a cost effective alternative for 68Ga-PSMA PET/CT. The aim of this study was to directly compare these two techniques in patients with prostate cancer. Methods: 28 man with prostate cancer were studied using 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in a short time period (<60 days). No intervention was done between the studies. Whole body PET/CT was done 60 minutes after IV injection of 2 MBq/Kg of 68Ga-PSMA. 99mTc-PSMA kit (PSMA I+S) was used for SPECT/CT and whole body imaging was performed 4 hours after IV injection of 740 MBq of 99mTc-PSMA. Images were interpreted independently and the results of each imaging were recorded. Results: The mean age of the patients was 64. 7± 9. 6 years old and the mean time difference between two sets of images was 16. 6± 13. 5 days. Abnormal uptake was seen in 25 (89. 2%) patients by 68Ga-PSMA PET/CT and 20 (71. 4%) patients with 99mTc-PSMA SPECT/CT. No patients with positive 99mTc-PSMA SPECT/CT had negative 68Ga-PSMA PET/CT. The mean number of detected lesions was 26. 07± 27. 5 by 68Ga-PSMA PET/CT and 10. 52± 10. 99 by 99mTc-PSMA SPECT/CT (P<0. 001). Detection of lymph nodes and bone metastases were not significantly different between two sets of imaging (P>0. 05), however 68Ga-PSMA PET/CT were more successful in detection of prostate bed lesions compared to 99mTc-PSMA scan. Interestingly, no patient with PSA level of >2. 1 ng/ml had discordant result between two sets of images. Conclusion: 99mTc-PSMA SPECT/CT is as accurate as 68Ga-PSMA PET/CT in M staging, however 68Ga-PSMA PET/CT detected more lesions compared to 99mTc-PSMA SPECT/CT. Detection rate was not significantly different between two techniques in patients with PSA levels>2. 1 ng/ml.

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    Cite

    APA: Copy

    Albalooshi, Batool, AL SHARHAN, MOUZA, BAGHERI, FARIBORZ, MIYANATH, SHABNA, RAY, BHAVNA, MUHASIN, MUHAMMED, & ZAKAVI, SEYED RASOUL. (2020). Direct comparison of 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in patients with prostate cancer. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, 8(1), 1-7. SID. https://sid.ir/paper/762765/en

    Vancouver: Copy

    Albalooshi Batool, AL SHARHAN MOUZA, BAGHERI FARIBORZ, MIYANATH SHABNA, RAY BHAVNA, MUHASIN MUHAMMED, ZAKAVI SEYED RASOUL. Direct comparison of 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in patients with prostate cancer. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY[Internet]. 2020;8(1):1-7. Available from: https://sid.ir/paper/762765/en

    IEEE: Copy

    Batool Albalooshi, MOUZA AL SHARHAN, FARIBORZ BAGHERI, SHABNA MIYANATH, BHAVNA RAY, MUHAMMED MUHASIN, and SEYED RASOUL ZAKAVI, “Direct comparison of 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in patients with prostate cancer,” ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, vol. 8, no. 1, pp. 1–7, 2020, [Online]. Available: https://sid.ir/paper/762765/en

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