Suppression of Menstrual-Related Migraine Attack Severity Using Pyridoxine, Thiamine, and Cyanocobalamin: A Quasi-Experimental Within-Subject Design

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TOGHA MANSOUREH; Rahmanzadeh Reza; Nematgorgani Shiva; YARI ZAHRA; RAZEGHI JAHROMI SOODEH; Refaeian Farshid

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Journal: Archives of Neuroscience Year:2020 | Volume:7 | Issue:3 Page(s): 0-0

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Title

Suppression of Menstrual-Related Migraine Attack Severity Using Pyridoxine, Thiamine, and Cyanocobalamin: A Quasi-Experimental Within-Subject Design

Author(s)

Keywords

Migraine

Headache

Prophylaxis

Neurobion

Neurotropic

Group B Vitamins

Vitamin B1

Vitamin B6

Vitamin B12

Abstract

Background: B-group vitamins can potentially contribute to Migraine Prophylaxis through various mechanisms. We conducted a quasi-experimental study to assess the efficacy and tolerability of a combination of vitamins B1, B6, and B12 (Neurobion) for Prophylaxis of menstruation-related Migraine attacks. Methods: Women diagnosed with menstrual-related Migraine, both chronic and episodic Headaches, were enrolled. The patients began Neurobion therapy one week before the menstruation cycle, and repeated the injection for three consecutive months; each ampoule contained 100 mg of vitamins B1 and B6 as well as 1000 g of Vitamin B12. Neurobion was used as an add-on therapy for patients receiving the same prophylactic therapy during the last two months before the start of the study. The outcome parameter examined the severity of menstrual-related Migraine attacks on a 10-point visual analog scale (VAS). Results: Three hundred eighty-three patients (169 with chronic Migraine and 214 with episodic Migraine) were included in the final analysis. The patients received treatment with a combination of vitamins B1, B6, and B12 with positive results. The mean intensity of menstrual-related Migraine attacks was reduced from 6. 7 on the 10-point VAS to 3. 2 (P < 0. 001) in patients with chronic Migraine. The mean severity of menstrual-related Migraine attacks was also reduced from 7. 2 to 3. 7 in patients with episodic Migraine (P < 0. 001). There was no significant difference in the reduction of Headache severity between the two groups of Migraineurs (P = 0. 985). Conclusions: Neurotropic vitamins, including pyridoxine, thiamine, and cyanocobalamin yielded significant reductions in the severity of menstrual-related Migraine attacks. Neurobion as a combination of vitamins B1, B6, and B12 appears to be well-tolerated and beneficial as an adjuvant in treatment and Prophylaxis of menstrual-related Migraine attacks. Further large-scale trials with long-term follow-up will be required to confirm our results.

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APA: Copy

TOGHA, MANSOUREH, Rahmanzadeh, Reza, Nematgorgani, Shiva, YARI, ZAHRA, RAZEGHI JAHROMI, SOODEH, & Refaeian, Farshid. (2020). Suppression of Menstrual-Related Migraine Attack Severity Using Pyridoxine, Thiamine, and Cyanocobalamin: A Quasi-Experimental Within-Subject Design. ARCHIVES OF NEUROSCIENCE, 7(3), 0-0. SID. https://sid.ir/paper/762899/en

Vancouver: Copy

TOGHA MANSOUREH, Rahmanzadeh Reza, Nematgorgani Shiva, YARI ZAHRA, RAZEGHI JAHROMI SOODEH, Refaeian Farshid. Suppression of Menstrual-Related Migraine Attack Severity Using Pyridoxine, Thiamine, and Cyanocobalamin: A Quasi-Experimental Within-Subject Design. ARCHIVES OF NEUROSCIENCE[Internet]. 2020;7(3):0-0. Available from: https://sid.ir/paper/762899/en

IEEE: Copy

MANSOUREH TOGHA, Reza Rahmanzadeh, Shiva Nematgorgani, ZAHRA YARI, SOODEH RAZEGHI JAHROMI, and Farshid Refaeian, “Suppression of Menstrual-Related Migraine Attack Severity Using Pyridoxine, Thiamine, and Cyanocobalamin: A Quasi-Experimental Within-Subject Design,” ARCHIVES OF NEUROSCIENCE, vol. 7, no. 3, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/762899/en

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