Prevalent Autoimmunities in Patients with Selective IgA Deficiency

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Pashangzadeh salar; SOHANI MAHSA

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Journal Paper

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Journal: Immunology and Genetics Journal Year:2019 | Volume:2 | Issue:3 Page(s): 44-52

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Information Journal Paper

Title

Prevalent Autoimmunities in Patients with Selective IgA Deficiency

Author(s)

Pashangzadeh salar | SOHANI MAHSA | Issue Writer Certificate

Keywords

Agammaglobulinemia

Autoimmunity

Primary immunodeficiency disorders (PIDs)

SIgAD

Abstract

Background/objectives: Among primary immunodeficiency (PID), selective immunoglobulin A deficiency (SIgAD) is the most prevalent type. SIgAD patients can be either asymptomatic or symptomatic. Symptomatic patients suffer from a wide range of manifestations including infections, allergy, Autoimmunity, and malignancy. SIgAD patients are more susceptible to some autoimmune diseases, while the exact mechanisms behind this association are not found yet. Therefore, this study was conducted in order to evaluate the possible association between autoimmune disease and specific clinical records or immunological data in SIgAD patients. Methods: The present cohort included 166 SIgAD patients who were diagnosed at the Research Centre for Immunodeficiencies at the children’ s medical Centre. A comprehensive history, demographic information, clinical manifestations, laboratory data were obtained from all patients to assess the autoimmune complications. Results: Autoimmunity was seen in 16 patients (9. 6%, 10 males and 6 females). The most common Autoimmunity types were juvenile idiopathic arthritis, vitiligo and alopecia (18. 8%). 9 patients (6. 5%) had a PID family history. Significant data that were higher in patients with Autoimmunity were the mean age at the study time (p=0. 019), rheumatoid problem (p=0. 043), liver problem (p=0. 031), IgG level (p=0. 006) and IgE level (p=0. 004). Conclusion: The association between SIgA deficiency and Autoimmunity could lead to severe clinical complications. So, it is better for immunologists to aware of these problems.

Cites

Allergy in Patients with Selective IgA Deficiency

References

Impaired Akt phosphorylation in B-cells of patients with common variable immunodeficiency

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APA: Copy

Pashangzadeh, salar, & SOHANI, MAHSA. (2019). Prevalent Autoimmunities in Patients with Selective IgA Deficiency. IMMUNOLOGY AND GENETICS JOURNA, 2(3), 44-52. SID. https://sid.ir/paper/763645/en

Vancouver: Copy

Pashangzadeh salar, SOHANI MAHSA. Prevalent Autoimmunities in Patients with Selective IgA Deficiency. IMMUNOLOGY AND GENETICS JOURNA[Internet]. 2019;2(3):44-52. Available from: https://sid.ir/paper/763645/en

IEEE: Copy

salar Pashangzadeh, and MAHSA SOHANI, “Prevalent Autoimmunities in Patients with Selective IgA Deficiency,” IMMUNOLOGY AND GENETICS JOURNA, vol. 2, no. 3, pp. 44–52, 2019, [Online]. Available: https://sid.ir/paper/763645/en

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