Effect of Endurance Training with Saffron Consumption on PGC1- Gene Expression in Hippocampus Tissue of Rats with Alzheimer’ s Disease

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Azarian Fatemeh; Farsi Sirous; HOSSEINI SEYED ALI; AZARBAYJANI MOHAMMAD ALI

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Journal Paper

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Journal: Annals of Military and Health Sciences Research Year:2020 | Volume:18 | Issue:1 Page(s): 0-0

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Title

Effect of Endurance Training with Saffron Consumption on PGC1- Gene Expression in Hippocampus Tissue of Rats with Alzheimer’ s Disease

Author(s)

Azarian Fatemeh | Farsi Sirous | HOSSEINI SEYED ALI | AZARBAYJANI MOHAMMAD ALI | Issue Writer Certificate

Keywords

Training

Saffron

PGC1-

Hippocampus

Alzheimer’s Disease

Abstract

Background: Alzheimer’ s disease (AD) is a type of cognitive impairment that disrupts the mitochondrial function and metabolism of neurons. Studies have shown that Training is a potent factor in enhancing mitochondrial biogenesis and Saffron with its antioxidant properties can improve neurodegenerative disorders effectively. Objectives: Accordingly, the aim of this study was to investigate the effect of endurance Training (ET) with Saffron consumption on peroxisome proliferator-activated receptor- coactivator (PGC-1 ) gene expression in hippocampal tissue of rats with AD. Methods: In this experimental study, 40rats withAD(induced by 8 mg/kg trimethyltin (TMT) injection were divided into five groups of eight rats, including (1) AD control, (2) ET, (3) ET with Saffron, (4) Saffron, and (5) sham. To investigate the effects of AD induction on PGC1- , eight healthy rats were assigned to the healthy control group. During eight weeks, groups 2 and 3 ran on a treadmill for eight weeks, three sessions per week, for 15-30 min at a speed of 15-20 m/min per session. Groups 3 and 4 received 25 mg/kg aqueous extract of Saffron peritoneally. One-way ANOVA, Tukey’ s post hoc, and two-way ANOVA tests were used for data analysis by SPSS software (P 0. 05). Results: Alzheimer’ s disease induction significantly reduced PGC1- gene expression (P = 0. 001) while ET significantly reduced PGC1- gene expression (P = 0. 01) in AD rats. Nevertheless, Saffron significantly increased PGC1- gene expression in AD rats (P = 0. 001). The interaction of ET and Saffron was significant in increasing PGC1- gene expression in AD rats (P = 0. 001). Conclusions: It seems that ET and Saffron consumption have interactive effects on the increase of PGC1- gene expression in the hippocampal tissue of rats with AD.

Cites

The Effect of Endurance Training and Saffron Extract on Plasma Levels of Interleukin 17 and 18 in Alzheimer’ s Rats by Trimethyltin Chloride

References

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APA: Copy

Azarian, Fatemeh, Farsi, Sirous, HOSSEINI, SEYED ALI, & AZARBAYJANI, MOHAMMAD ALI. (2020). Effect of Endurance Training with Saffron Consumption on PGC1- Gene Expression in Hippocampus Tissue of Rats with Alzheimer’ s Disease. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 18(1), 0-0. SID. https://sid.ir/paper/764146/en

Vancouver: Copy

Azarian Fatemeh, Farsi Sirous, HOSSEINI SEYED ALI, AZARBAYJANI MOHAMMAD ALI. Effect of Endurance Training with Saffron Consumption on PGC1- Gene Expression in Hippocampus Tissue of Rats with Alzheimer’ s Disease. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2020;18(1):0-0. Available from: https://sid.ir/paper/764146/en

IEEE: Copy

Fatemeh Azarian, Sirous Farsi, SEYED ALI HOSSEINI, and MOHAMMAD ALI AZARBAYJANI, “Effect of Endurance Training with Saffron Consumption on PGC1- Gene Expression in Hippocampus Tissue of Rats with Alzheimer’ s Disease,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 18, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/764146/en

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