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Title

Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models

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  0-0

Abstract

 Background: Lipid Disorders are a well-documented risk factor for chronic kidney disease (CKD), but the impact of lipid abnormalities in the progression of the disease remains mixed. Objectives: The current study aimed to extend the existing knowledge about the effect of Lipid Disorders in disease progression from moderate to severe stage using Flexible parametric survival models. Methods: This retrospective cohort study included 308 moderate CKD patients who received the nephrologist follow-up visits at the nephrology clinic, Ilam (Iran), from 2012 to 2019. The survival time was determined based on the time medically diagnosed with moderate stages (GFR = 59-55 mL/min per 1. 73m2) to the time of progression to the severe stage (GFR = 29-25 mL/min per 1. 73m2) hazard using flexible parametric survival models. Results: In univariate analysis, high levels of TG, LDL, and cholesterol were important risk factors which affect the CKD progression. The hazard of patients with TG > 200 mg/dL was 1. 69 times higher than patients with desirable TG levels (P = 0. 09). Moreover, for patients with LDL > 160 mg/dL, the hazard was 2. 12 times higher than patients with desirable LDL levels (P = 0. 01). The hazard of patients with total cholesterol levels > 240 mg/dL was 2. 10 times higher than patients with desirable cholesterol levels (P = 0. 003). The adjusted model was shown to better fit the PH model. Cholesterol levels > 240 mg/dL remains a significant risk factor for CKD progression (P = 0. 03). Conclusions: Effective treatment programs should pay closer attention to screening and treatment of hyperlipidemia in patients diagnosed with moderate CKD.

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    APA: Copy

    Mozafari, Aliashraf, MANSOURNIA, MOHAMMAD ALI, SAYEHMIRI, KOUROSH, Ghiasi, Bahareh, YASERI, MEHDI, & AZAMI, GOLNAZ. (2020). Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 22(7), 0-0. SID. https://sid.ir/paper/764208/en

    Vancouver: Copy

    Mozafari Aliashraf, MANSOURNIA MOHAMMAD ALI, SAYEHMIRI KOUROSH, Ghiasi Bahareh, YASERI MEHDI, AZAMI GOLNAZ. Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2020;22(7):0-0. Available from: https://sid.ir/paper/764208/en

    IEEE: Copy

    Aliashraf Mozafari, MOHAMMAD ALI MANSOURNIA, KOUROSH SAYEHMIRI, Bahareh Ghiasi, MEHDI YASERI, and GOLNAZ AZAMI, “Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 22, no. 7, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/764208/en

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