Increasing radiosensitivity by the combined inhibition of PARP1 and PI3K in BRCA1-mutated triple negative breast cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZHOU J.; TANG L.Y.; ZHANG X.H.; WANG J.; Yang L.C.; WU S.G.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Radiation Research Year:2020 | Volume:18 | Issue:2 Page(s): 283-293

Download Full-Text

View:

199

Download:

150

Cites:

Information Journal Paper

Title

Increasing radiosensitivity by the combined inhibition of PARP1 and PI3K in BRCA1-mutated triple negative breast cancer

Author(s)

Keywords

Breast cancer

radiation

BRCA1

PARP1

PI3K

Abstract

Background: To evaluate the radiosensitizing effect of co-targeting of poly (ADP-ribose) polymerase-1 (PARP1) (AZD2461) and phosphoinositide-3-kinase (PI3K) (LY294002) in Breast cancer 1, early onset gene (BRCA1)-mutated triple negative Breast cancer (TNBC) treated in vitro. Materials and Methods: We established HCC1937-PARP1 cells by transfection. Cell proliferation, cell viability, cell cycle, and cell apoptosis were measured and analyzed. Western blotting and quantitative real-time polymerase chain reaction assays were performed. Results: The cell viability of HCC1937 and HCC1937-PARP1 cells was significantly decreased under 5 Gy of irradiation. Cell apoptosis was remarkably increased by irradiation, whereas overexpression of PARP1 resulted in substantial resistance to the radiation-induced changes. Combined inhibition of PARP1 and PI3K enhanced radiation-induced apoptosis and significantly inhibited cell proliferation compared with single-agent treatment. The PI3K inhibitor induced changes in the cell cycle distribution, but the PARP1 inhibitor did not. The expression levels of LKB1, PHLPP and INPP4B increased after combined inhibition of PARP1 or PI3K compared with irradiation alone. Moreover, combined inhibition of PARP1 and PI3K resulted in increased expression of INPP4B when compared with that induced by single-agent treatment. Conclusion: Combined inhibition of PARP1 and PI3K might be an effective therapeutic strategy to enhance radiosensitivity in BRCA1-mutated TNBC.

Cites

No record.

References

No record.

Cite

APA: Copy

ZHOU, J., TANG, L.Y., ZHANG, X.H., WANG, J., Yang, L.C., & WU, S.G.. (2020). Increasing radiosensitivity by the combined inhibition of PARP1 and PI3K in BRCA1-mutated triple negative breast cancer. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 18(2), 283-293. SID. https://sid.ir/paper/764249/en

Vancouver: Copy

ZHOU J., TANG L.Y., ZHANG X.H., WANG J., Yang L.C., WU S.G.. Increasing radiosensitivity by the combined inhibition of PARP1 and PI3K in BRCA1-mutated triple negative breast cancer. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2020;18(2):283-293. Available from: https://sid.ir/paper/764249/en

IEEE: Copy

J. ZHOU, L.Y. TANG, X.H. ZHANG, J. WANG, L.C. Yang, and S.G. WU, “Increasing radiosensitivity by the combined inhibition of PARP1 and PI3K in BRCA1-mutated triple negative breast cancer,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 18, no. 2, pp. 283–293, 2020, [Online]. Available: https://sid.ir/paper/764249/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops