Liposomal Vincristine as a Bridge Therapy Prior to CAR-T Therapy in Relapsed and Refractory Diffuse Large B-Cell Lymphoma?

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Chadha Juskaran; Hussein Shafinaz; Zhan Yougen; Shulman Jonah; Brody Joshua; Ratner Lynn; Steinberg Amir

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Hematology-Oncology and Stem Cell Research Year:2019 | Volume:13 | Issue:2 Page(s): 102-107

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Liposomal Vincristine as a Bridge Therapy Prior to CAR-T Therapy in Relapsed and Refractory Diffuse Large B-Cell Lymphoma?

Author(s)

Keywords

CAR-T

Liposomal vincristine

DLBCL

Heavily pretreated

Autologous SCT

Abstract

We report a case of a 76-year-old male with a history of relapsed and refractory diffuse large B-cell lymphoma (DLBCL). Our patient was initially treated with front line chemotherapy along with central nervous system (CNS) prophylaxis with complete response. He subsequently relapsed, was sensitive to second-line chemotherapy, and underwent autologous stem cell transplantation achieving a complete remission. Only a few months after transplant, the patient suffered his second relapse and was deemed a candidate for Chimeric Antigen Receptor T-Cell Therapy (CAR-T). Given his aggressive disease, combined with the time needed to generate CAR-T cells, a multidisciplinary team recommended to treat our patient with Liposomal vincristine in combination with rituximab as a bridge therapy. Durable responses have been seen using Liposomal vincristine based on results from a recent phase II trial in Heavily pretreated patients with DLBCL1. This therapy was effective in stabilizing and reducing active disease in our patient. This case looks to illustrate the use of Liposomal vincristine in combination with immunotherapy in a novel setting bridging highly selected patients with active and refractory lymphoma prior to CAR-T. Moreover, we expanded an additional therapeutic point, highlighting the importance of optimal disease control prior to CAR-T cell harvesting, as recent literature has shown that residual malignant cells in the pheresis product may be inadvertently be transfected with the CAR gene, resulting in resistance and further relapse2.

Cites

No record.

References

No record.

Cite

APA: Copy

Chadha, Juskaran, Hussein, Shafinaz, Zhan, Yougen, Shulman, Jonah, Brody, Joshua, Ratner, Lynn, & Steinberg, Amir. (2019). Liposomal Vincristine as a Bridge Therapy Prior to CAR-T Therapy in Relapsed and Refractory Diffuse Large B-Cell Lymphoma?. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), 13(2), 102-107. SID. https://sid.ir/paper/764305/en

Vancouver: Copy

Chadha Juskaran, Hussein Shafinaz, Zhan Yougen, Shulman Jonah, Brody Joshua, Ratner Lynn, Steinberg Amir. Liposomal Vincristine as a Bridge Therapy Prior to CAR-T Therapy in Relapsed and Refractory Diffuse Large B-Cell Lymphoma?. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)[Internet]. 2019;13(2):102-107. Available from: https://sid.ir/paper/764305/en

IEEE: Copy

Juskaran Chadha, Shafinaz Hussein, Yougen Zhan, Jonah Shulman, Joshua Brody, Lynn Ratner, and Amir Steinberg, “Liposomal Vincristine as a Bridge Therapy Prior to CAR-T Therapy in Relapsed and Refractory Diffuse Large B-Cell Lymphoma?,” INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), vol. 13, no. 2, pp. 102–107, 2019, [Online]. Available: https://sid.ir/paper/764305/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops