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Information Journal Paper

Title

The Anxiolytic and Antidepressant Effects of Tanacetum polycephalum in the Pentylenetetrazole Kindled Rats

Pages

  13-20

Abstract

 Background and objective: epilepsy is one the most prevalent neurological illnesses which affects behavioral statuses like anxiety, depression and balance. Based on the anti-inflammatory and antioxidant properties of Tanacetum polycephalum, its effect on anxiety and depression caused by pentylenetetrazole (PTZ)-kindling in rats was investigated. Methods: In order to prepare the required extract, aerial part of Tanacetum polycephalum was powdered (100 g) and macerated in 1 L of ethanol (80%) for 24 h. Twenty-four rats were randomly assigned to four groups: PTZ (sub-threshold dose 35 mg/kg for one month, intraperitoneal (i. p)), PTZ + phenobarbital (30 mg/kg, i. p), PTZ + plant extract (300 mg/kg, i. p), and PTZ + plant extract (600 mg/kg, i. p). Elevated plus maze (EPM), forced swim test (FST) and rotarod test were employed to assess the anxiety parameters, antidepressant and balance potential, respectively. Results: Tanacetum polycephalum extract administered at the doses of 300, and 600 mg/kg, exert antidepressant-like activity in the FST test and reduced the immobility time. In the EPM test, the extract at the same doses produced anxiolytic-like effects. Also, the rats which received the extract showed a significant improvement in the rotarod test in contrast to the PTZ group. Conclusion: The findings from current study showed that Tanacetum polycephalum could ameliorate neurobehavioral parameters of anxiety and depression in the PTZ-kindled rats.

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    Cite

    APA: Copy

    AZIZI, VAHID, Allahyari, Farzin, Rezaali, Farnoosh, & Hossein, Abdolkarim. (2020). The Anxiolytic and Antidepressant Effects of Tanacetum polycephalum in the Pentylenetetrazole Kindled Rats. RESEARCH JOURNAL OF PHARMACOGNOSY, 7(2), 13-20. SID. https://sid.ir/paper/764322/en

    Vancouver: Copy

    AZIZI VAHID, Allahyari Farzin, Rezaali Farnoosh, Hossein Abdolkarim. The Anxiolytic and Antidepressant Effects of Tanacetum polycephalum in the Pentylenetetrazole Kindled Rats. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2020;7(2):13-20. Available from: https://sid.ir/paper/764322/en

    IEEE: Copy

    VAHID AZIZI, Farzin Allahyari, Farnoosh Rezaali, and Abdolkarim Hossein, “The Anxiolytic and Antidepressant Effects of Tanacetum polycephalum in the Pentylenetetrazole Kindled Rats,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 7, no. 2, pp. 13–20, 2020, [Online]. Available: https://sid.ir/paper/764322/en

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