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Information Journal Paper

Title

Phytochemical, anti-inflammatory and analgesic properties of stembark extract and fractions of Lonchocarpus sericeus Poir. (Papilionaceae) in albino mice

Pages

  593-584

Abstract

 Objective: Lonchocarpus sericeus stembark decoction has been extensively employed in folkloric medicine in many parts of Nigeria as a remedy for pain as well as inflammation. The plant was studied for its anti-inflammatory as well as analgesic potency using standard biological models. Materials and Methods: The stembark of L. sericeus was evaluated for anti-inflammatory properties using egg albumin and xylene-induced oedema models. The pain-relieving property was evaluated using acetic acid-induced writhing and thermally-induced pain models. Median lethal dose determination (intraperitoneal LD50), quantification of some phytochemicals as well as phytochemical screening were also performed. Results: The LD50 of stembark extract of L. sericeus was found to be 3, 100 mg/kg (i. p). The crude extract and fractions (310-930 mg/kg) effectively reduced oedema caused by egg albumin and xylene and exhibited high analgesic properties in inhibiting pain induced by acetic acid and heat. These reductions were dose-dependent and statistically significant (p<0. 05-0. 001) when compared to distilled water and similar to prototype drugs employed. Quantitative determinations of some bio-active constituents of the plant showed a higher flavonoid content (0. 52± 0. 02 mg/100 g) compared to alkaloids (0. 36± 0. 02 mg/100 g) and flavonoids (0. 49± 0. 03 mg/100 g). Phytochemical screening of the stembark showed the presence of alkaloids, cardiac glycosides, flavonoids terpenes, tannins and saponins. Conclusion: These results imply that the stembark extract of L. sericeus possesses anti-inflammatory and analgesic potency and these data validate its wide use in folkloric medicine for inflammation and pain management.

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    APA: Copy

    Emmanuel, Uwemedimo, Onyekachi, Johnbull, & Uchenna, Okenwa. (2020). Phytochemical, anti-inflammatory and analgesic properties of stembark extract and fractions of Lonchocarpus sericeus Poir. (Papilionaceae) in albino mice. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(6), 593-584. SID. https://sid.ir/paper/764863/en

    Vancouver: Copy

    Emmanuel Uwemedimo, Onyekachi Johnbull, Uchenna Okenwa. Phytochemical, anti-inflammatory and analgesic properties of stembark extract and fractions of Lonchocarpus sericeus Poir. (Papilionaceae) in albino mice. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(6):593-584. Available from: https://sid.ir/paper/764863/en

    IEEE: Copy

    Uwemedimo Emmanuel, Johnbull Onyekachi, and Okenwa Uchenna, “Phytochemical, anti-inflammatory and analgesic properties of stembark extract and fractions of Lonchocarpus sericeus Poir. (Papilionaceae) in albino mice,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 6, pp. 593–584, 2020, [Online]. Available: https://sid.ir/paper/764863/en

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