EFFECT OF ORAL VANADYL SULPHATE ON ULTRA STRUCTURE OF PANCREATIC ISLETS BETA CELLS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

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AHMADI S.A.D.; KARIMIAN S.M.; SOTOUDEH MASOUD; BAHADORI MOSLEM; DEHGHAN GHOLAM ABAS

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Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2009 | Volume:14 | Issue:2 (SERIAL NUMBER 52) Page(s): 1-13

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Title

EFFECT OF ORAL VANADYL SULPHATE ON ULTRA STRUCTURE OF PANCREATIC ISLETS BETA CELLS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Author(s)

Keywords

STREPTOZOTOCINQ2

VANADYL SULFATEQ3

PLASMA GLUCOSEQ3

ULTRASTRUCTUREQ3

DIABETESQ3

Abstract

Background and Aim: Considering insulin like effects of vanadium salts, these compounds have been evaluated as a therapeutic agent for treatment of DIABETES mellitus in the experimental models of the disease in animals. This study was performed to study the ultra structure of islet b cells in STREPTOZOTOCIN (STZ)- induced DIABETES in rats after treatment with VANADYL SULFATE (VS). Material and Methods: DIABETES was induced in male Wistar rats by intravenous injection of 40 mg/kg STZ. Equal volume of normal saline was injected via lateral tail vein in sham animals. Seven days after injection animals in both groups were divided into treated and control groups. VS was added to the drinking water of the diabetic treated (DT) and Sham treated (NT) animals with a concentration of 0.5 mg/ml for one week and 1 mg/ml up to three months. Untreated diabetic (DC) and sham rats (NC) received tap water during this period. Two months later all animals were killed. Langerhans islets were isolated from exocrine parts by use of collagen digestion, and were fixed in glutaraldehyde. Ultra structures of islet beta cells were studied by means of transmission electron microscope.Results: VS treatment led to amelioration of the symptoms of DIABETES including hyperglycemia and polydepsia in DT rats. DC rats remained diabetic during the period of study. No significant changes were observed in PLASMA GLUCOSE and fluid intake of NT animals. Ultra structural studies of islet b cells of DT rats showed normal cells with normal chromatin distribution, well-developed rough endoplasmic reticulum, increased cytoplasmic granules and no clear sign of cell injury. Lymphocytic infiltration was not detected in langerhans islets of DT group. Nuclear pyknosis, cytoplasmic vacuolization, lymphocytic infiltration and signs of cell death such as cell necrosis were found in the islets of b cells of DC rats. Cytoplasm of islets b cells of NT rats were more granular in comparison to NC rats.Conclusion: Considering the results of this study we concluded that amelioration of DIABETES signs in VS treated STZ induced diabetic rats are accompanied by preservation of islets b cell ULTRASTRUCTURE.

Cites

THE PROTECTIVE EFFECT OF ALOE VERA ON HISTOLOGICAL STRUCTURE OF ENDOCRINE PORTION OF PANCREAS GLAND IN THE DIABETIC RAT

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APA: Copy

AHMADI, S.A.D., KARIMIAN, S.M., SOTOUDEH, MASOUD, BAHADORI, MOSLEM, & DEHGHAN, GHOLAM ABAS. (2009). EFFECT OF ORAL VANADYL SULPHATE ON ULTRA STRUCTURE OF PANCREATIC ISLETS BETA CELLS IN STREPTOZOTOCIN INDUCED DIABETIC RATS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 14(2 (SERIAL NUMBER 52)), 1-13. SID. https://sid.ir/paper/76489/en

Vancouver: Copy

AHMADI S.A.D., KARIMIAN S.M., SOTOUDEH MASOUD, BAHADORI MOSLEM, DEHGHAN GHOLAM ABAS. EFFECT OF ORAL VANADYL SULPHATE ON ULTRA STRUCTURE OF PANCREATIC ISLETS BETA CELLS IN STREPTOZOTOCIN INDUCED DIABETIC RATS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;14(2 (SERIAL NUMBER 52)):1-13. Available from: https://sid.ir/paper/76489/en

IEEE: Copy

S.A.D. AHMADI, S.M. KARIMIAN, MASOUD SOTOUDEH, MOSLEM BAHADORI, and GHOLAM ABAS DEHGHAN, “EFFECT OF ORAL VANADYL SULPHATE ON ULTRA STRUCTURE OF PANCREATIC ISLETS BETA CELLS IN STREPTOZOTOCIN INDUCED DIABETIC RATS,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 2 (SERIAL NUMBER 52), pp. 1–13, 2009, [Online]. Available: https://sid.ir/paper/76489/en

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