Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

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GHAFFARI SAMAD; Parvizian Nashmil; POURAFKARI LEILI; SEPARHAM AHMAD; Hajizadeh Reza; D.Nader Nader; Javanshir Elnaz; SEPEHRVAND NARIMAN; TAJLIL AREZOU; NASIRI BABAK

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Journal: Journal of Cardiovascular and Thoracic Research Year:2020 | Volume:12 | Issue:1 Page(s): 56-62

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Title

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Author(s)

Keywords

Pulmonary Thromboembolism

Platelet

Mean Platelet Volume

Platelet Distribution Width

Mortaity

Abstract

Introduction: Given the role of Platelets in thrombus formation, markers of Platelet activation may be able to predict outcomes in patients with acute Pulmonary Thromboembolism (PTE). Methods: In a prospective cohort study, 492 patients with acute PTE were enrolled. Patients were evaluated for Platelet indices including mean Platelet volume (MPV), Platelet distribution width (PDW), and Platelet-lymphocyte-ratio (PLR), as well as for the simplified Pulmonary Embolism Severity Index (PESI) risk score. The primary endpoint was in-hospital all-cause mortality. Major adverse cardiopulmonary events (MACPE, composite of mortality, thrombolysis, mechanical ventilation and surgical embolectomy during index hospitalization) and all-cause death during follow-up were secondary endpoints. Results: MPV, PDW and PLR were 9. 9± 1. 0 fl, 13. 5± 6. 1%, and 14. 7± 14. 5, respectively, in the total cohort. Whilst MPV was higher in those with adverse events (10. 1± 1. 0 vs 9. 9± 1. 0 fl; P = 0. 019), PDW and PLR were not different between two groups. MPV with a cut-off point of 9. 85 fl had a sensitivity of 81% and a specificity of 50% in predicting in-hospital mortality, but it had lower performance in predicting MACPE (Area under the curve: AUC 0. 58; 95%CI 0. 52-0. 63) or long-term mortality (AUC 0. 54; 95% CI 0. 47-0. 61). The AUC for all these three markers were lower than the AUC calculated for the simplified PESI score (0. 80; 0. 71-0. 88). Conclusion: Platelet indices had only fair-to-good predictive performance in predicting in-hospital all-cause death. Established PTE risk scoring models such as simplified PESI outperform these indices in predicting adverse outcomes.

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References

Diagnostic validity of hematologic parameters in evaluation of massive pulmonary embolism

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APA: Copy

GHAFFARI, SAMAD, Parvizian, Nashmil, POURAFKARI, LEILI, SEPARHAM, AHMAD, Hajizadeh, Reza, D.Nader, Nader, Javanshir, Elnaz, SEPEHRVAND, NARIMAN, TAJLIL, AREZOU, & NASIRI, BABAK. (2020). Prognostic value of platelet indices in patients with acute pulmonary thromboembolism. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 12(1), 56-62. SID. https://sid.ir/paper/765429/en

Vancouver: Copy

GHAFFARI SAMAD, Parvizian Nashmil, POURAFKARI LEILI, SEPARHAM AHMAD, Hajizadeh Reza, D.Nader Nader, Javanshir Elnaz, SEPEHRVAND NARIMAN, TAJLIL AREZOU, NASIRI BABAK. Prognostic value of platelet indices in patients with acute pulmonary thromboembolism. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2020;12(1):56-62. Available from: https://sid.ir/paper/765429/en

IEEE: Copy

SAMAD GHAFFARI, Nashmil Parvizian, LEILI POURAFKARI, AHMAD SEPARHAM, Reza Hajizadeh, Nader D.Nader, Elnaz Javanshir, NARIMAN SEPEHRVAND, AREZOU TAJLIL, and BABAK NASIRI, “Prognostic value of platelet indices in patients with acute pulmonary thromboembolism,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 12, no. 1, pp. 56–62, 2020, [Online]. Available: https://sid.ir/paper/765429/en

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