Effects of different doses of X-ray radiation on nerve regeneration after sciatic nerve injury in a rat model

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ZHANG Y.; JIANG B.; Zhao J.J.; ZHOU J.P.; Zuo Z.C.; Qian Z.Y.; Wang P.J.

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Journal: International Journal of Radiation Research Year:2020 | Volume:18 | Issue:1 Page(s): 23-31

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Title

Effects of different doses of X-ray radiation on nerve regeneration after sciatic nerve injury in a rat model

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Keywords

Peripheral nerve injury

nerve regeneration

X-ray irradiation

Abstract

Background: Physical agents, such as ultrasound, can promote functional restoration and regenerative processes of the peripheral nervous system. However, little is known about the effects of X-ray radiation on nerve regeneration after Peripheral nerve injury. The aim of the present study was to investigate the effects of various doses of X-ray radiation on nerve regeneration after sciatic nerve injury in rats. Materials and Methods: The sciatic nerves of Sprague-Dawley rats were transected and repaired via epineurium end-to-end neurorrhaphy. Eighty rats each received single and local X-ray doses of 0 Gy, 0. 2 Gy, 1 Gy, 7 Gy and 14 Gy. Functional and morphological assessments of the process of nerve regeneration were performed by using various measurement tools. Results: Compared with the 0 Gy, 0. 2 Gy and 14 Gy groups, the 1 Gy and 7 Gy radiation groups experienced significantly increased sciatic functional index, motor nerve conductive velocity (MNCV), expression of S-100, mean diameter of axons, and thickness of myelin sheaths and decreased perineural scar tissue. There were no differences between the 1 Gy group and the 7 Gy group or between the 0 Gy group, the 0. 2 Gy group and the 14 Gy group with the exception of MNCV and the expression level of S-100. Conclusion: X-ray radiation in doses of 1 Gy and 7 Gy promoted nerve regeneration after sciatic nerve injury in a rat model. The dose of 14 Gy exerted inhibitory effects, and 0. 2 Gy exerted no significant effect on nerve regeneration.

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APA: Copy

ZHANG, Y., JIANG, B., Zhao, J.J., ZHOU, J.P., Zuo, Z.C., Qian, Z.Y., & Wang, P.J.. (2020). Effects of different doses of X-ray radiation on nerve regeneration after sciatic nerve injury in a rat model. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 18(1), 23-31. SID. https://sid.ir/paper/766089/en

Vancouver: Copy

ZHANG Y., JIANG B., Zhao J.J., ZHOU J.P., Zuo Z.C., Qian Z.Y., Wang P.J.. Effects of different doses of X-ray radiation on nerve regeneration after sciatic nerve injury in a rat model. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2020;18(1):23-31. Available from: https://sid.ir/paper/766089/en

IEEE: Copy

Y. ZHANG, B. JIANG, J.J. Zhao, J.P. ZHOU, Z.C. Zuo, Z.Y. Qian, and P.J. Wang, “Effects of different doses of X-ray radiation on nerve regeneration after sciatic nerve injury in a rat model,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 18, no. 1, pp. 23–31, 2020, [Online]. Available: https://sid.ir/paper/766089/en

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