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Information Journal Paper

Title

Acute, Sub-acute and Cell Toxicity of Allium elburzense Bulb Hydroalcoholic Extract

Pages

  65-75

Abstract

 Background and objectives: Allium elburzense is an endemic plant in north of Iran with some nutritional and medicinal applications; however, there is no data on its safety profile. This study was aimed to investigate cytotoxicity, acute and sub-acute toxicity of hydroalcoholic extract of A. elburzense bulb. Methods: Total phenolic content of the extract was measured using Folin-Ciocalteu method. For cytotoxicity assay, human umbilical vein endothelial cells (HUVECs) were used. In acute toxicity study, single oral dose of 2000 mg/kg was administered in female and male Wistar rats and they were monitored for two weeks. In sub-acute test, 125, 250 and 500 mg/kg/day of extract were orally administered for four weeks. Results: Total phenolic content was estimated as 32. 8 ± 2. 5 mg gallic acid equivalent/g of the extract. The extract showed IC50 value of 366. 4 μ g/mL (95% CI = 246. 4-566. 1) in HUVECs after 24 h exposure. In acute study, there was no sign of toxicity and no mortality; however, significant increase in relative spleen weight and ALP activity and mild inflammation in kidney tissue were observed. LD50 ˃ 2000 mg/kg was estimated for A. elburzense bulb extract. In sub-acute assay, there were significant elevations in relative spleen weight, blood urea level, AST, ALT, ALP, total WBC, lymphocyte and neutrophil count and significant decrease in blood sugar and triglyceride levels at higher doses of the extract. Conclusion: Allium elburzense bulb extract may be considered as safe at doses lower than 500 mg/kg in rats; however, assessment of liver and kidney functions is recommended during chronic uses.

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    Cite

    APA: Copy

    Yavarian, Bahareh, SAFAEIAN, LEILA, ZOLFAGHARI, BEHZAD, ETEBARI, MAHMOUD, & SHARIFI, HAMIDREZA. (2020). Acute, Sub-acute and Cell Toxicity of Allium elburzense Bulb Hydroalcoholic Extract. RESEARCH JOURNAL OF PHARMACOGNOSY, 7(3), 65-75. SID. https://sid.ir/paper/766164/en

    Vancouver: Copy

    Yavarian Bahareh, SAFAEIAN LEILA, ZOLFAGHARI BEHZAD, ETEBARI MAHMOUD, SHARIFI HAMIDREZA. Acute, Sub-acute and Cell Toxicity of Allium elburzense Bulb Hydroalcoholic Extract. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2020;7(3):65-75. Available from: https://sid.ir/paper/766164/en

    IEEE: Copy

    Bahareh Yavarian, LEILA SAFAEIAN, BEHZAD ZOLFAGHARI, MAHMOUD ETEBARI, and HAMIDREZA SHARIFI, “Acute, Sub-acute and Cell Toxicity of Allium elburzense Bulb Hydroalcoholic Extract,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 7, no. 3, pp. 65–75, 2020, [Online]. Available: https://sid.ir/paper/766164/en

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