Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

183
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

68
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients

Pages

  285-292

Abstract

 Objectives: Vitamin D deficiency is prevalent in Heart failure (HF) and the anti-inflammatory impacts of Vitamin D may affect the pathogenesis of HF. Therefore, the present study aimed to investigate the effect of Vitamin D supplementation on echocardiographic and biochemical factors in Vitamin D-deficient HF patients. Materials and Methods: To this end, 39 HF patients with 25(OH)D ≤ 20 ng/mL participated in the current double-blind, randomized, and placebo-controlled trial, who belonged to class III, New York Heart Association classification. About 50 000 IU Vitamin D3 (group D + ) or placebo (group D-) were prescribed within 2 months. Then, the ejection fraction (EF%), tumor necrosis factor alpha (TNF-α ), B-type Natriuretic peptide (BNP), and high sensitive C-reactive protein (hs-CRP) were assessed before and after supplementation. Results: The mean serum level of 25(OH)D increased markedly in D + group (P < 0. 001). The mean increase of EF% was 5. 3± 9. 03% (P = 0. 03) and the decrease of TNF-α (-0. 09 pg/mL, P < 0. 001) and BNP (-3. 14 ng/mL, P = 0. 04) were statistically significant in D + group after supplementation. In addition, the blood concentration of BNP declined significantly in D + group compared to placebo while hs-CRP and TNF-α levels failed to differ between the two groups. Conclusions: The results revealed that Vitamin D could be effective against inflammation and thus its supplementation may reduce the severity of HF by improving the serum level of BNP and EF%. However, more clinical trials are required to approve the beneficial role of Vitamin D in HF patients.

Cites

References

Cite

APA: Copy

HOSEINZADEH, FAHIMEH, JANGI OSKOUEI, NADER, & GHAVAMZADEH, SAEID. (2019). The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 6(3), 285-292. SID. https://sid.ir/paper/766976/en

Vancouver: Copy

HOSEINZADEH FAHIMEH, JANGI OSKOUEI NADER, GHAVAMZADEH SAEID. The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2019;6(3):285-292. Available from: https://sid.ir/paper/766976/en

IEEE: Copy

FAHIMEH HOSEINZADEH, NADER JANGI OSKOUEI, and SAEID GHAVAMZADEH, “The Effect of Vitamin D Supplementation on Inflammation and Markers of Vascular Function in Heart Failure Patients,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 6, no. 3, pp. 285–292, 2019, [Online]. Available: https://sid.ir/paper/766976/en

Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top