ASESSMENT OF THE ANTINOCICEPTIVE, ANTIINFLAMMATORY AND ACUTE TOXICITY EFFECTS OF DUCROSIA

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ASGARI NEMATIAN M.; YAGHMAEI P.; MOHAMMADI S.

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:22 | Issue:3 Page(s): 74-84

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Title

ASESSMENT OF THE ANTINOCICEPTIVE, ANTIINFLAMMATORY AND ACUTE TOXICITY EFFECTS OF DUCROSIA

Author(s)

ASGARI NEMATIAN M. | YAGHMAEI P. | MOHAMMADI S. | Issue Writer Certificate

Keywords

ANTI-INFLAMMATORYQ3

ANALGESICQ3

DUCROSIA ANETHIFOLIAQ1

MEDICINAL PLANTSQ2

Abstract

Background and Aim: DUCROSIA ANETHIFOLIA (Moshgak) is one of the most important herbs used in traditional medicine for treatment of anxiety and insomnia. The aim of this study was to evaluate the ANTI-INFLAMMATORY and ANALGESIC effects of DUCROSIA ANETHIFOLIA leaf essential oil (DAEO) in male mice.Material and Methods: This experimental study included 84 male mice. For evaluation of pain, we used pain assessment tests (writhing, tail-flick and formalin) and animals were divided into control group and experimental groups. The experimental groups treated with the essential oil (30, 100 and 300mg/kg), morphine, and naloxone plus 300 mg/kg of essential oil. We used Xylene test for evaluation of ANTI-INFLAMMATORY effect, and divided the animals into 5 groups: control, DAEO (10, 50, and 100 mg kg) and dexamethasone.Results: In tail-flick and writhing tests, application of a dose of 300 mg/kg of DAEO showed a significant ANALGESIC effect (P<0.01) in the test groups compared to that in the control group. In the formalin test, a dose of 100 mg/kg of DAEO in the chronic phase reduced pain scores in the test groups compared to the scores in the control group (P<0.05). In addition, in Xylene test, treatment with both doses of 50 and 100 mg/kg of essential oil led to reduced ear swelling in the rats (3.8 ±0.1, 4.1±0.8, respectively), compared to that in the control group.Conclusion: Intraperitoneal administration of DAEO can produce ANALGESIC and ANTI-INFLAMMATORY effects.

Cites

Anti-inflammatory and Anti-nociceptive Activities of Hydroalcoholic Extract of Rosa canina L. Fruit in Male Mice

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APA: Copy

ASGARI NEMATIAN, M., YAGHMAEI, P., & MOHAMMADI, S.. (2017). ASESSMENT OF THE ANTINOCICEPTIVE, ANTIINFLAMMATORY AND ACUTE TOXICITY EFFECTS OF DUCROSIA. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 22(3 ), 74-84. SID. https://sid.ir/paper/76708/en

Vancouver: Copy

ASGARI NEMATIAN M., YAGHMAEI P., MOHAMMADI S.. ASESSMENT OF THE ANTINOCICEPTIVE, ANTIINFLAMMATORY AND ACUTE TOXICITY EFFECTS OF DUCROSIA. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;22(3 ):74-84. Available from: https://sid.ir/paper/76708/en

IEEE: Copy

M. ASGARI NEMATIAN, P. YAGHMAEI, and S. MOHAMMADI, “ASESSMENT OF THE ANTINOCICEPTIVE, ANTIINFLAMMATORY AND ACUTE TOXICITY EFFECTS OF DUCROSIA,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 3 , pp. 74–84, 2017, [Online]. Available: https://sid.ir/paper/76708/en

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