مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

122
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

82
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Protective Effect of Time-Modulated Cimetidine on Methotrexate-induced Liver Toxicity

Pages

  133-142

Abstract

 Background: Methotrexate (MTX) is one of the frequently used chemotherapeutic agents, especially in hematological malignancies and solid tumors. Objectives: MTX hepatoToxicity symptoms range from elevations in serum aminotransferases to hepatocyte necrosis and fibrosis. The Time of medication administration significantly impacts treatment outcomes. Hence this study evaluated the protective effect of Timemodulated Cimetidine (CT) against MTX-induced hepatoToxicity in albino rats. Methods: Thirty-six adult male albino rats were randomized into 6 groups. Group A (control) was injected intraperitoneally (IP) with normal saline (0. 2 mL) for 24 h. Group B received CT (20 mg/kg IP) for 24 h. Group C was treated IP with MTX (20 mg/kg) for 24 h. Group C (pre-treatment) was injected IP with CT one hour before MTX administration for 24 h. Group E (co-treatment group) was co-treated IP with CT and MTX for 24 h. Group F (posttreatment group) was treated IP with one dose of MTX one hour before CT injection for 24 h. After treatments, the rats were weighed and euthanized. Blood samples were collected and their blood samples were evaluated for serum Liver function markers, also Liver samples were excised and used for biochemical and histological studies. Results: The Liver of MTX-treated rats was characterized by hepatocyte necrosis. Aminotransferases, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, conjugated bilirubin, total bilirubin, and malondialdehyde activities were significantly (P<0. 001) up-regulated in MTX-treated rats. However, glutathione, catalase, superoxide dismutase, and glutathione peroxidase activities were significantly (P<0. 001) down-regulated in MTX-treated rats. The above hepatotoxic changes were significantly attenuated in rats pre-treated (P<0. 001), co-treated (P<0. 01), and post-treated (P<0. 05) with CT when compared to MTX group. Conclusion: However, pre-treatment with CT was most effective, hence it may be clinically useful for MTX-induced hepatoToxicity

Cites

  • No record.

    • References

    Cite

    APA: Copy

    ADIKWU, ELIAS, & Nnaedozie, Emmanuel. (2020). Protective Effect of Time-Modulated Cimetidine on Methotrexate-induced Liver Toxicity. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 6(2), 133-142. SID. https://sid.ir/paper/768120/en

    Vancouver: Copy

    ADIKWU ELIAS, Nnaedozie Emmanuel. Protective Effect of Time-Modulated Cimetidine on Methotrexate-induced Liver Toxicity. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2020;6(2):133-142. Available from: https://sid.ir/paper/768120/en

    IEEE: Copy

    ELIAS ADIKWU, and Emmanuel Nnaedozie, “Protective Effect of Time-Modulated Cimetidine on Methotrexate-induced Liver Toxicity,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 6, no. 2, pp. 133–142, 2020, [Online]. Available: https://sid.ir/paper/768120/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button