The Relationship Between 25-Hydroxyvitamin D3 and Hepatitis B Surface Antigen Levels in Patients with Chronic Hepatitis B in Japan

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ITOKAWA NORIO; ATSUKAWA MASANORI; TSUBOTA AKIHITO; ABE HIROSHI; SHIMADA NORITOMO; Okubo Tomomi; Arai Taeang; NAKAGAWA AI; Kondo Chisa; Aizawa Yoshio; IWAKIRI KATSUHIKO

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Journal: Hepatitis Monthly Year:2018 | Volume:18 | Issue:5 Page(s): 0-0

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Title

The Relationship Between 25-Hydroxyvitamin D3 and Hepatitis B Surface Antigen Levels in Patients with Chronic Hepatitis B in Japan

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Keywords

Hepatitis B Surface Antigen Levels

25-Hydroxyvitamin D3 Level

Vitamin D Deficiency

Abstract

Background: Although there are many reports on the relationship between serum 25-Hydroxyvitamin D3 Levels and chronic liver diseases, the relevance of the former to the latter is still unclear. Objectives: This study aimed at clarifying the relationship between serum 25-Hydroxyvitamin D3 Levels and HBV-related markers, such as HBV-DNA, hepatitis B surface antigen (HBsAg), and hepatitis B virus core-related antigen (HBcrAg) in patients with chronic hepatitis B. Methods: This was a multicenter retrospective study. The subjects consisted of 236 consecutive untreated patients with chronic hepatitis B. Serum 25-Hydroxyvitamin D3 Levels were measured by double-antibody radioimmunoassay. The 25-Hydroxyvitamin D3 Levels were divided to three groups: 20 ng/mL for deficiency, 21 to 29 ng/mL for insufficiency, and 30 ng/mL for sufficiency. Results: The subjects consisted of 127 males and 109 females, with a median age of 57 years (range, 15 to 84 years). The patients with positive HBeAg and genotype C accounted for 14. 4% and 63. 1%, respectively. The median HBV-DNA level and HBsAg level were 684 IU/mL and 750 IU/mL, respectively. The median serum 25-Hydroxyvitamin D3 Level was significantly lower in patients (21. 0 ng/mL) than in healthy volunteers (25. 0 ng/mL, P = 0. 013). The median serum 25-Hydroxyvitamin D3 Level in patients with a serum HBsAg level 1000 IU/mL was significantly lower than that in patients with a serum HBsAg level of < 1000 U/mL (P = 8. 06 1 0-3). The incidence of the HBsAg level 1000 IU/mL was 55. 8% in patients with Vitamin D Deficiency and 3 8. 2% in patients with vitamin D insufficiency/sufficiency (P = 8. 92 10-3). On multivariate analysis, female gender, the cold season, and a serum HBsAg level of 1000 IU/mL were independently associated with Vitamin D Deficiency. From the opposite viewpoint, Vitamin D Deficiency and high serum HBcrAg level were independent factors associated with an HBsAg level of 1000 IU/mL. Conclusions: This study suggests that serum vitamin D level is closely and negatively correlated with the HBsAg level in chronic hepatitis B patients.

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APA: Copy

ITOKAWA, NORIO, ATSUKAWA, MASANORI, TSUBOTA, AKIHITO, ABE, HIROSHI, SHIMADA, NORITOMO, Okubo, Tomomi, Arai, Taeang, NAKAGAWA, AI, Kondo, Chisa, Aizawa, Yoshio, & IWAKIRI, KATSUHIKO. (2018). The Relationship Between 25-Hydroxyvitamin D3 and Hepatitis B Surface Antigen Levels in Patients with Chronic Hepatitis B in Japan. HEPATITIS MONTHLY, 18(5), 0-0. SID. https://sid.ir/paper/768784/en

Vancouver: Copy

ITOKAWA NORIO, ATSUKAWA MASANORI, TSUBOTA AKIHITO, ABE HIROSHI, SHIMADA NORITOMO, Okubo Tomomi, Arai Taeang, NAKAGAWA AI, Kondo Chisa, Aizawa Yoshio, IWAKIRI KATSUHIKO. The Relationship Between 25-Hydroxyvitamin D3 and Hepatitis B Surface Antigen Levels in Patients with Chronic Hepatitis B in Japan. HEPATITIS MONTHLY[Internet]. 2018;18(5):0-0. Available from: https://sid.ir/paper/768784/en

IEEE: Copy

NORIO ITOKAWA, MASANORI ATSUKAWA, AKIHITO TSUBOTA, HIROSHI ABE, NORITOMO SHIMADA, Tomomi Okubo, Taeang Arai, AI NAKAGAWA, Chisa Kondo, Yoshio Aizawa, and KATSUHIKO IWAKIRI, “The Relationship Between 25-Hydroxyvitamin D3 and Hepatitis B Surface Antigen Levels in Patients with Chronic Hepatitis B in Japan,” HEPATITIS MONTHLY, vol. 18, no. 5, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/768784/en

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