Comparison of Adding Sufentanil and Low-Dose Epinephrine to Bupivacaine in Spinal Anesthesia: A Randomized, Double-Blind, Clinical Trial

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DERAKHSHAN POOYA; IMANI FARNAD; KOLEINI ZAHRA SADAT; Barati Amin

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Journal: Anesthesiology and Pain Medicine Year:2018 | Volume:8 | Issue:5 Page(s): 0-0

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Title

Comparison of Adding Sufentanil and Low-Dose Epinephrine to Bupivacaine in Spinal Anesthesia: A Randomized, Double-Blind, Clinical Trial

Author(s)

DERAKHSHAN POOYA | IMANI FARNAD | KOLEINI ZAHRA SADAT | Barati Amin | Issue Writer Certificate

Keywords

Spinal Anesthesia

Bupivacaine

Sufentanil

Epinephrine

Abstract

Background: Spinal Anesthesia, as an effective approach, is widely performed in various surgeries with possible complications. To reduce the side effects, many adjuvants are used to maintain desirable sensory and motor blockades and increase the quality and prolong the analgesia. Methods: In the current double-blind, randomized clinical trial, 105 participants aged 18-60 years with ASA class I or II who were candidate for lower limb surgery were randomly allocated to patients receiving Bupivacaine 15 mg + normal saline 1 mL (B group), Bupivacaine 15 mg + Epinephrine 10 µ g (BE group), and Bupivacaine 15 mg + sufentanyl 5 µ g (BS group). Onset of sensory blockade was determined bilaterally with the pinprick test. The maximum Bromage scale was assessed for the onset of motor blockage. Recovery from sensory and motor blockades was also evaluated. Pain score (visual analogue scale; VAS) was determined for all participants. Results: Onset of sensory and motor blockades was statistically different among the groups. Intrathecal Bupivacaine (the placebo group) had the lowest onset of sensory blockage, whereas the onset of motor blockade was significantly shorter with the administration of Sufentanil + Epinephrine (P = 0. 001) (BS and BE groups). However, Epinephrine (BE group) did not significantly prolong sensory and motor blockade. Recovery time from sensory and motor blockade was significantly lower with the Bupivacaine alone (the placebo group). Conclusions: The current study results suggested that the combination of 10 µ g Epinephrine and 5 µ g Sufentanil + Bupivacaine did not prolong the sensory and motor blockades in Spinal Anesthesia for lower limb surgery, compared with Bupivacaine alone.

Cites

A comparative study on effect of low dose Ketamine versus Dexamethasone on intraoperative nausea and vomiting during cesarean section under spinal anesthesia

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APA: Copy

DERAKHSHAN, POOYA, IMANI, FARNAD, KOLEINI, ZAHRA SADAT, & Barati, Amin. (2018). Comparison of Adding Sufentanil and Low-Dose Epinephrine to Bupivacaine in Spinal Anesthesia: A Randomized, Double-Blind, Clinical Trial. ANESTHESIOLOGY AND PAIN MEDICINE, 8(5), 0-0. SID. https://sid.ir/paper/768940/en

Vancouver: Copy

DERAKHSHAN POOYA, IMANI FARNAD, KOLEINI ZAHRA SADAT, Barati Amin. Comparison of Adding Sufentanil and Low-Dose Epinephrine to Bupivacaine in Spinal Anesthesia: A Randomized, Double-Blind, Clinical Trial. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2018;8(5):0-0. Available from: https://sid.ir/paper/768940/en

IEEE: Copy

POOYA DERAKHSHAN, FARNAD IMANI, ZAHRA SADAT KOLEINI, and Amin Barati, “Comparison of Adding Sufentanil and Low-Dose Epinephrine to Bupivacaine in Spinal Anesthesia: A Randomized, Double-Blind, Clinical Trial,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 8, no. 5, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/768940/en

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