Normal Expression of Cytotoxic T-lymphocyte-As sociated Protein4 (CTLA4) in a Lipopolysaccharide-Responsive and Beige-like Anchor Protein (LRBA)Deficient Patient

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Salami Fereshte

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Journal Paper

Paper Information

Journal: Immunology and Genetics Journal Year:2020 | Volume:3 | Issue:3 Page(s): 53-58

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Information Journal Paper

Title

Normal Expression of Cytotoxic T-lymphocyte-As sociated Protein4 (CTLA4) in a Lipopolysaccharide-Responsive and Beige-like Anchor Protein (LRBA)Deficient Patient

Author(s)

Salami Fereshte | Issue Writer Certificate

Keywords

LRBA

hypogammaglobulinemia

enteropathy

CTLA4

Abstract

Biallelic lipopolysaccharide-responsive and beige-like anchor (LRBA) mutations could lead to an immune dysregulation disorder, labeled as LRBA deficiency. A wide spectrum of clinical manifesta tion was shown to be associated with recurrent infections, enteropathy, hypogammaglobulinemia, and autoimmune complications. Notably, LRBA interacts with cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) by its recycling to the T-cell surface. Accordingly, LRBA deficiency abolishes CTLA4 protein expression. In this study, we presented a case with a homozygous mutation in the LRBA gene as well as a normal level of CTLA4 protein. In this regard, the immunologist assays of this patient revealed low immunoglobulin levels, CD4+ helper T cells, and CD19+ B cells.

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APA: Copy

Salami, Fereshte. (2020). Normal Expression of Cytotoxic T-lymphocyte-As sociated Protein4 (CTLA4) in a Lipopolysaccharide-Responsive and Beige-like Anchor Protein (LRBA)Deficient Patient. IMMUNOLOGY AND GENETICS JOURNA, 3(3), 53-58. SID. https://sid.ir/paper/769182/en

Vancouver: Copy

Salami Fereshte. Normal Expression of Cytotoxic T-lymphocyte-As sociated Protein4 (CTLA4) in a Lipopolysaccharide-Responsive and Beige-like Anchor Protein (LRBA)Deficient Patient. IMMUNOLOGY AND GENETICS JOURNA[Internet]. 2020;3(3):53-58. Available from: https://sid.ir/paper/769182/en

IEEE: Copy

Fereshte Salami, “Normal Expression of Cytotoxic T-lymphocyte-As sociated Protein4 (CTLA4) in a Lipopolysaccharide-Responsive and Beige-like Anchor Protein (LRBA)Deficient Patient,” IMMUNOLOGY AND GENETICS JOURNA, vol. 3, no. 3, pp. 53–58, 2020, [Online]. Available: https://sid.ir/paper/769182/en

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