Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AMIN FATEMEH; ROOHBAKHSH ALI; Memarzia Arghavan; KAZERANI HAMID REZA; BOSKABADY MOHAMMAD HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2020 | Volume:10 | Issue:5 Page(s): 513-522

Download Full-Text

View:

161

Download:

125

Cites:

Information Journal Paper

Title

Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol

Author(s)

Keywords

Paraquat Zataria multiflora Carvacrol Oxidative biomarkers Inflammation

Abstract

Objective: Paraquat (PQ) is a herbicide which induces oxidative stress and inflammation. Anti-inflammatory and anti-oxidant effects were shown for Zataria multiflora (Z. multiflora) and carvacrol previously. The effects of Z. multiflora hydroalcoholic extract and carvacrol on systemic inflammation and oxidative stress induced by inhaled PQ were examined in this study. Materials and Methods: Six groups of male rats used in this study were as follows: control group exposed to normal saline aerosol, one group exposed to PQ 54 mg/m3 aerosol, animals exposed to PQ 54 mg/m3 and treated with Z. multiflora (200 and 800 mg/kg/day) or carvacrol (20 and 80 mg/kg/day) for 16 days after the end of exposure to PQ. Exposure to PQ was performed 8 times, every other day, each time for 30 min. After the end of the treatment period, different variables were measured. Results: Significant increases in nitrite (NO2), malondialdehyde (MDA) and interleukin (IL)-6 serum levels but significant reduction of interferon-gamma (IFN-γ ) serum levels as well as IFN-γ /IL-6 ratio were observed in PQ-exposed compared to control group (p<0. 01 for MDA and IL-6, p<0. 001 for other cases). Treatment with both doses of the extract and carvacrol specially at high dose, reduced MDA, NO2, and IL-6 but increased IFN-γ and IFN-γ /IL-6 ratio compared to un-treated PQ exposed group (p<0. 05 to p<0. 001). Conclusion: Treatment with Z. multiflora and carvacrol improved systemic inflammation oxidative biomarkers induced by inhaled PQ which may indicate therapeutic potential of the plant and its constituent, carvacrol in systemic inflammation and oxidative biomarkers induced by inhaled PQ.

Cites

Protective effects of quercetin against hyperglycemia-induced oxidative stress in hepatic HepG2 cell line

References

Cite

APA: Copy

AMIN, FATEMEH, ROOHBAKHSH, ALI, Memarzia, Arghavan, KAZERANI, HAMID REZA, & BOSKABADY, MOHAMMAD HOSSEIN. (2020). Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(5), 513-522. SID. https://sid.ir/paper/769220/en

Vancouver: Copy

AMIN FATEMEH, ROOHBAKHSH ALI, Memarzia Arghavan, KAZERANI HAMID REZA, BOSKABADY MOHAMMAD HOSSEIN. Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(5):513-522. Available from: https://sid.ir/paper/769220/en

IEEE: Copy

FATEMEH AMIN, ALI ROOHBAKHSH, Arghavan Memarzia, HAMID REZA KAZERANI, and MOHAMMAD HOSSEIN BOSKABADY, “Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 5, pp. 513–522, 2020, [Online]. Available: https://sid.ir/paper/769220/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops