Effects of Insulin on Fibronectin Alterations in Sciatic Nerve of Diabetic Rats-A Brief Report

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Safari Manochehr; Aldaghi Niloofar; SAMENI HAMID REZA; ALDAGHI MOHAMMAD REZA

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Journal Paper

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Journal: Iranian Journal of Diabetes and Obesity Year:2020 | Volume:12 | Issue:1 Page(s): 54-57

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Title

Effects of Insulin on Fibronectin Alterations in Sciatic Nerve of Diabetic Rats-A Brief Report

Author(s)

Safari Manochehr | Aldaghi Niloofar | SAMENI HAMID REZA | ALDAGHI MOHAMMAD REZA | Issue Writer Certificate

Keywords

Diabetes

Sciatic nerve

Basement membrane proteins

Fibronectin

Abstract

Objective: Alteration in the Basement membrane proteins maybe associated with diabetic neuropathy. Fibronectin is one of the most important components of peripheral nerves basement membrane. In this study we investigated the effects of insulin administration on prevention of alteration in Fibronectin contents of Sciatic nerve in diabetic rats. Materials and Methods: Twenty-four wistar rats were divided into control, diabetic and diabetic with insulin treatment groups. Three months after Diabetes induction, we measured blood glucose level, body weight and then expression of Fibronectin in Sciatic nerves of rats were evaluated by real time polymerase chain reaction (PCR) and immunohistochemical study. Results: Intensity of Fibronectin immunoreactivity in the perineurium and endoneurium of Sciatic nerves significantly increased in diabetic without treatment group compared to control group (P-value< 0. 001). Conclusion: This finding suggested that diabetic neuropathy resulted in increased of Fibronectin contents in Sciatic nerves of rats.

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References

Ischemic injury leads to extracellular matrix alterations in retina and optic nerve

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APA: Copy

Safari, Manochehr, Aldaghi, Niloofar, SAMENI, HAMID REZA, & ALDAGHI, MOHAMMAD REZA. (2020). Effects of Insulin on Fibronectin Alterations in Sciatic Nerve of Diabetic Rats-A Brief Report. IRANIAN JOURNAL OF DIABETES AND OBESITY, 12(1), 54-57. SID. https://sid.ir/paper/769865/en

Vancouver: Copy

Safari Manochehr, Aldaghi Niloofar, SAMENI HAMID REZA, ALDAGHI MOHAMMAD REZA. Effects of Insulin on Fibronectin Alterations in Sciatic Nerve of Diabetic Rats-A Brief Report. IRANIAN JOURNAL OF DIABETES AND OBESITY[Internet]. 2020;12(1):54-57. Available from: https://sid.ir/paper/769865/en

IEEE: Copy

Manochehr Safari, Niloofar Aldaghi, HAMID REZA SAMENI, and MOHAMMAD REZA ALDAGHI, “Effects of Insulin on Fibronectin Alterations in Sciatic Nerve of Diabetic Rats-A Brief Report,” IRANIAN JOURNAL OF DIABETES AND OBESITY, vol. 12, no. 1, pp. 54–57, 2020, [Online]. Available: https://sid.ir/paper/769865/en

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