Comparison of Growth Parameters in Two Groups of Children with Chronic Renal Failure Treated with and without Growth Hormone Replacement Therapy

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Darabi Azadeh; Mohamadi Taze Abadi Javad; Ghane Sharbaf Fatemeh; GHAEMI NOSRAT; AZARFAR ANOUSH; RAVANSHAD YALDA; Sarvari Gholamreza; Ekrami Noghabi Mina; GHAHREMANI SARA

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Journal: Journal of Pediatric Perspectives Year:2019 | Volume:7 | Issue:8 (68) Page(s): 9883-9892

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Title

Comparison of Growth Parameters in Two Groups of Children with Chronic Renal Failure Treated with and without Growth Hormone Replacement Therapy

Author(s)

Keywords

Body mass index

Children

Chronic Renal Failure

Growth hormone

Height

Weight

Abstract

Background: The aim of the present study was to evaluate the effect of Growth hormone on growth parameters such as Z scores for Height, Weight, and Body mass index (BMI), and Height velocity in two groups of Children with Chronic Renal Failure (CRF) treated with and without Growth hormone. Materials and Methods: This longitudinal study was conducted on all Children aged 6 months to 16 years with a short suture who had chronic kidney disease and indication of the Growth hormone (GH) replacement therapy during the years 2016 to 2018 at Sheikh Nephrology Clinic. In our study, growth parameters including Z scores for Height, Weight, and BMI were measured in each patient at the beginning and at the end of follow-up. To assess the effect of Growth hormone, growth parameters were compared between the two groups at the beginning and at the end of follow-up. Also, Height velocity was compared in the Growth hormone treated and untreated groups. Results: Results showed that a significant difference between the two groups in terms of Height velocity in the first year (P=0. 013) and the whole period (P=0. 003). Also, there was no significant difference between two groups in terms of Height Z score at the start of follow-up (P=0. 101), but it was significant at the end of the follow-up (P=0. 044). Results of comparing Weight Z scores, BMI values and laboratory parameters in two groups at the beginning and at the end of the follow-up showed no significant differences. Conclusion: The results of this study showed that Growth hormone replacement therapy can improve Height growth in patients with CKD-induced growth impairment.

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References

Growth and Nutrition in Pediatric Chronic Kidney Disease

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APA: Copy

Darabi, Azadeh, Mohamadi Taze Abadi, Javad, Ghane Sharbaf, Fatemeh, GHAEMI, NOSRAT, AZARFAR, ANOUSH, RAVANSHAD, YALDA, Sarvari, Gholamreza, Ekrami Noghabi, Mina, & GHAHREMANI, SARA. (2019). Comparison of Growth Parameters in Two Groups of Children with Chronic Renal Failure Treated with and without Growth Hormone Replacement Therapy. INTERNATIONAL JOURNAL OF PEDIATRICS, 7(8 (68)), 9883-9892. SID. https://sid.ir/paper/770440/en

Vancouver: Copy

Darabi Azadeh, Mohamadi Taze Abadi Javad, Ghane Sharbaf Fatemeh, GHAEMI NOSRAT, AZARFAR ANOUSH, RAVANSHAD YALDA, Sarvari Gholamreza, Ekrami Noghabi Mina, GHAHREMANI SARA. Comparison of Growth Parameters in Two Groups of Children with Chronic Renal Failure Treated with and without Growth Hormone Replacement Therapy. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2019;7(8 (68)):9883-9892. Available from: https://sid.ir/paper/770440/en

IEEE: Copy

Azadeh Darabi, Javad Mohamadi Taze Abadi, Fatemeh Ghane Sharbaf, NOSRAT GHAEMI, ANOUSH AZARFAR, YALDA RAVANSHAD, Gholamreza Sarvari, Mina Ekrami Noghabi, and SARA GHAHREMANI, “Comparison of Growth Parameters in Two Groups of Children with Chronic Renal Failure Treated with and without Growth Hormone Replacement Therapy,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 7, no. 8 (68), pp. 9883–9892, 2019, [Online]. Available: https://sid.ir/paper/770440/en

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