Evaluation of Transdermal Formulations of Metoclopramide Prepared Using Arachis Oil and Liquid Paraffin as Permeation Enhancers

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Eraga Sylvester O.; Arhewoh Matthew I.; Meko Ogochukwu A.

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Journal: Pharmaceutical and Biomedical Research Year:2020 | Volume:6 | Issue:3 Page(s): 213-222

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Information Journal Paper

Title

Evaluation of Transdermal Formulations of Metoclopramide Prepared Using Arachis Oil and Liquid Paraffin as Permeation Enhancers

Author(s)

Eraga Sylvester O. | Arhewoh Matthew I. | Meko Ogochukwu A. | Issue Writer Certificate

Keywords

Metoclopramide

Transdermal film

Nausea

Liquid paraffin

Arachis oil

Abstract

Background: The study aimed to evaluate the effect of Arachis oil and Liquid paraffin on Metoclopramide release from Transdermal films. Objectives: Batches of Metoclopramide films were prepared with hydroxypropyl methyl cellulose (HPMC), Arachis oil or Liquid paraffin and Tween 80 as plasticizer. The films were evaluated for their physiochemical properties, in vitro and ex vivo drug release and drug release kinetics. Drug-excipient interactions were investigated using Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR) spectroscopy. Methods: The Transdermal films had a weight range of 0. 22-0. 24 g, folding endurance of 300-306, percentage moisture content and uptake of 2%-10% and 19%-110%, respectively and drug content of 98%-104%. There was similar condition in vitro release profile for the films but their ex vivo profiles exhibited variable drug release with the P3 (30% Arachis oil) giving the highest drug (almost 100%) release. Results: The release kinetics of Metoclopramide followed the first order and Korsemeyer-Peppas models more closely as seen in their correlation coefficients (R2) of 0. 9832 and 0. 9560, respectively. Drug-excipient compatibility studies showed no interactions between excipients and Metoclopramide. Conclusion: The formulated Transdermal films showed controlled drug release over a period of 12 h. Arachis oil and Liquid paraffin showed similar permeation enhancing ability. These enhanced permeation properties of the films could be helpful in the development of alternative route for Metoclopramide administration in the management of emesis with improved patient acceptance.

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References

Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action

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APA: Copy

Eraga, Sylvester O., Arhewoh, Matthew I., & Meko, Ogochukwu A.. (2020). Evaluation of Transdermal Formulations of Metoclopramide Prepared Using Arachis Oil and Liquid Paraffin as Permeation Enhancers. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 6(3), 213-222. SID. https://sid.ir/paper/770913/en

Vancouver: Copy

Eraga Sylvester O., Arhewoh Matthew I., Meko Ogochukwu A.. Evaluation of Transdermal Formulations of Metoclopramide Prepared Using Arachis Oil and Liquid Paraffin as Permeation Enhancers. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2020;6(3):213-222. Available from: https://sid.ir/paper/770913/en

IEEE: Copy

Sylvester O. Eraga, Matthew I. Arhewoh, and Ogochukwu A. Meko, “Evaluation of Transdermal Formulations of Metoclopramide Prepared Using Arachis Oil and Liquid Paraffin as Permeation Enhancers,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 6, no. 3, pp. 213–222, 2020, [Online]. Available: https://sid.ir/paper/770913/en

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