Role of dimethyl fumarate in the treatment of glioblastoma multiforme: A review article

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AHMADI BENI REZA; NAJAFI ALI; Savar Seyed Mehrdad; MOHEBBI NIAYESH; KHOSHNEVISAN ALIREZA

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Journal: Current Journal of Neurology Year:2019 | Volume:18 | Issue:3 Page(s): 127-133

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Title

Role of dimethyl fumarate in the treatment of glioblastoma multiforme: A review article

Author(s)

Keywords

Brain Neoplasms

Glioblastoma

Fumarates

Dimethyl Fumarate

Neuroprotective Agents

Drug Repurposing

Abstract

Glioblastoma multiforme (GBM), the most frequent malignant and aggressive primary brain tumor, is characterized by genetically unstable heterogeneous cells, diffused growth pattern, microvascular proliferation, and resistance to chemotherapy. Extensive investigations are being carried out to identify the molecular origin of resistance to chemo-and radio-therapy in GBM and find novel targets for therapy to improve overall survival rate. Dimethyl Fumarate (DMF) has been shown to be a safe drug with limited short and long-term side effects, and fumaric acid esters (FAEs), including DMF, present both anti-oxidative and anti-inflammatory activity in different cell types and tissues. DMF has also anti-tumoral and neuroprotective effects and so it could be repurposed in the treatment of this invasive tumor in the future. Here, we have reviewed DMF pharmacokinetics and different mechanisms by which DMF could have therapeutic effects on GBM.

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APA: Copy

AHMADI BENI, REZA, NAJAFI, ALI, Savar, Seyed Mehrdad, MOHEBBI, NIAYESH, & KHOSHNEVISAN, ALIREZA. (2019). Role of dimethyl fumarate in the treatment of glioblastoma multiforme: A review article. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 18(3), 127-133. SID. https://sid.ir/paper/771018/en

Vancouver: Copy

AHMADI BENI REZA, NAJAFI ALI, Savar Seyed Mehrdad, MOHEBBI NIAYESH, KHOSHNEVISAN ALIREZA. Role of dimethyl fumarate in the treatment of glioblastoma multiforme: A review article. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2019;18(3):127-133. Available from: https://sid.ir/paper/771018/en

IEEE: Copy

REZA AHMADI BENI, ALI NAJAFI, Seyed Mehrdad Savar, NIAYESH MOHEBBI, and ALIREZA KHOSHNEVISAN, “Role of dimethyl fumarate in the treatment of glioblastoma multiforme: A review article,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 18, no. 3, pp. 127–133, 2019, [Online]. Available: https://sid.ir/paper/771018/en

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