Significance of EGFR mRNA Expression in Luminal and Triple Negative Breast Tumors

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Darbeheshti Farzaneh; IZADI PANTEA; EMAMI RAZAVI AMIR NADER; KAMALI FATEMEH; YEKANINEJAD MIR SAEED; Tavakkoli Bazzaz Javad

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Journal: International Journal of Cancer Management Year:2018 | Volume:11 | Issue:2 Page(s): 0-0

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Title

Significance of EGFR mRNA Expression in Luminal and Triple Negative Breast Tumors

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Keywords

Breast Cancer

EGFR mRNA Expression

Luminal Subtype

Triple Negative Subtype

Abstract

Background: The epidermal growth factor receptor (EGFR) has critical roles in signal transduction pathways, leading to cell growth and differentiation. EGFR expression levels vary among different breast tumor subtypes and ethnic groups. On the other hand, the relationship between EGFR expression at the mRNA level with clinicopathological characteristics in Breast Cancer has rarely been reported. Objectives: The present study focuses on the assessment of EGFR mRNA Expression in breast tumors and the association of its expression with various clinicopathological features in Iranian patients with Breast Cancer. Methods: In this cross sectional study, the expression of EGFR was assessed by real time PCR technique in tumors of 52 Iranian women (27 luminal and 25 triple negative tumors) with primary Breast Cancer and 6 normal breast tissues. Results: The results of this study showed that EGFR mRNA was overexpressed only in triple negative tumors, and there is a high frequency of EGFR underexpression in luminal breast tumors, unlike triple negative tumors. We demonstrated that there is a significant positive correlation (r = 0. 662) between EGFR expression and the size of luminal tumors. In the current study, the increased expression of EGFR is significantly associated with estrogen receptor (ER) negative, progesterone receptor (PR) negative, and grade III in breast tumors. Conclusions: These findings suggest that the majority of patients with triple negative tumors are likely eligible to receive the anti-EGFR therapies. Also, it seems that EGFR expression probably has an association withtumorsize in Luminal Subtype of breast tumors.

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APA: Copy

Darbeheshti, Farzaneh, IZADI, PANTEA, EMAMI RAZAVI, AMIR NADER, KAMALI, FATEMEH, YEKANINEJAD, MIR SAEED, & Tavakkoli Bazzaz, Javad. (2018). Significance of EGFR mRNA Expression in Luminal and Triple Negative Breast Tumors. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 11(2), 0-0. SID. https://sid.ir/paper/772181/en

Vancouver: Copy

Darbeheshti Farzaneh, IZADI PANTEA, EMAMI RAZAVI AMIR NADER, KAMALI FATEMEH, YEKANINEJAD MIR SAEED, Tavakkoli Bazzaz Javad. Significance of EGFR mRNA Expression in Luminal and Triple Negative Breast Tumors. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2018;11(2):0-0. Available from: https://sid.ir/paper/772181/en

IEEE: Copy

Farzaneh Darbeheshti, PANTEA IZADI, AMIR NADER EMAMI RAZAVI, FATEMEH KAMALI, MIR SAEED YEKANINEJAD, and Javad Tavakkoli Bazzaz, “Significance of EGFR mRNA Expression in Luminal and Triple Negative Breast Tumors,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 11, no. 2, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/772181/en

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