مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

179
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

100
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Glucose-lowering potential of Guiera senegalensis roots in a diabetic rat model

Pages

  653-663

Abstract

 Objective: Guiera senegalensis is distributed in the Sudano-Sahelian zone and used traditionally for the treatment of diabetes. This study was designed to assess the hypoglycemic effects of G. senegalensis in Wistar diabetic rats. Materials and Methods: Phytochemical analysis was carried out on aqueous and methanolic extracts of G. senegalensis. Type 2 diabetes was induced in male rats using nicotinamide/streptozotocin (65 mg/kg/110 mg/kg, i. p. ). After diabetes induction, normal and negative control groups received distilled water, positive control group received glibenclamide (0. 25 mg/kg) and the others group received aqueous and methanolic extracts (200 and 400 mg/kg, each) orally for 4 weeks. Glycaemia, body weight, insulin level, total cholesterol (TC), high density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDL-c), triglycerides (TG), aspartate amino transferase (AST) and alanine amino transferase (ALT) activities, urea and creatinine (Cr) were evaluated. Results: The content of phenols, flavonoids and tannins were 34. 54 mg gallic acid equivalent (GAE)/gE, 4. 86 mg quercetin equivalent (QE)/gE and 16. 81 mg catechin equivalent (EC)/gE in the aqueous extract, respectively. Phenol (26. 01 mg GAE/gE), flavonoid (4. 47 mg QE/gE) and tannin (7. 67 mg EC/gE) contents were also obtained for the methanolic extract. G. senegalensis and glibenclamide resulted in a significant increase (p<0. 001) in body weight and HDL-c in diabetic group rats receiving glibenclamide and different doses of extracts. . The level of insulin, glycaemia, TG, TC, LDL-c, urea and creatinine significantly decreased (p<0. 05 to 0. 001) in diabetic animals treated with G. senegalensis extracts. Conclusion: These results confirm the potential of G. senegalensis for the treatment of diabetes and its complications.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Miaffo, David, Ntchapda, Fidele, Guessom Kamgue, Oulianovie, Talba Mahamad, Abba, & Kamanyi, Albert. (2020). Glucose-lowering potential of Guiera senegalensis roots in a diabetic rat model. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(6), 653-663. SID. https://sid.ir/paper/772702/en

    Vancouver: Copy

    Miaffo David, Ntchapda Fidele, Guessom Kamgue Oulianovie, Talba Mahamad Abba, Kamanyi Albert. Glucose-lowering potential of Guiera senegalensis roots in a diabetic rat model. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(6):653-663. Available from: https://sid.ir/paper/772702/en

    IEEE: Copy

    David Miaffo, Fidele Ntchapda, Oulianovie Guessom Kamgue, Abba Talba Mahamad, and Albert Kamanyi, “Glucose-lowering potential of Guiera senegalensis roots in a diabetic rat model,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 6, pp. 653–663, 2020, [Online]. Available: https://sid.ir/paper/772702/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button