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Information Journal Paper

Title

The Effect of Aerobic Training on Tumor Necrosis Factor alpha, Hypoxia-Inducible Factor-1 alpha & Vascular Endothelial Growth Factor Gene Expression in Cardiac Tissue of Diabetic Rats

Pages

  90-97

Abstract

 Objective: The goal of this research was to determine the influence of 4 weeks Aerobic training on gene expression of Tumor necrosis factor alpha (TNF-α ), Hypoxia-inducible factor-1 alpha (HIF-1α ) and Vascular endothelial growth factor (VEGF) in the cardiac tissue of diabetic rats. Materials and Methods: In an experimental study, 30 male wistar rats were partitioned into three groups (n=10), diabetic Aerobic training, diabetic control and healthy control (n=10). Induction of type 2diabetes (T2DM) was done by intraperitoneal infusion of streptozotocin. The progressive Aerobic training protocol entailed 4 weeks, 5 sessions per week running on treadmill at velocity of 20 m/min for 60 min. The gene expression of TNF-α , VEGF and HIF-1α were measured by real time & PCR. One way analysis of variance and bonferroni test were applied to analysis the data. The significant level was set at P-value< 0. 05. Results: The results indicated that the Aerobic training induced significant decrease in TNF-α mRNA (P-value< 0. 001) and significant increase in HIF-1α mRNA (P-value< 0. 001) and VEGF mRNA (P-value< 0. 001) compared to diabetic control group. Conclusion: It appears that Aerobic training with reduction of TNF-α issues an affirmative effect on angiogenesis, as a result, it improves diabetic cardiac.

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    APA: Copy

    Bakhtiari, Fariba, MATIN HOMAEE, HASAN, & GHAZALIAN, FARSHAD. (2020). The Effect of Aerobic Training on Tumor Necrosis Factor alpha, Hypoxia-Inducible Factor-1 alpha & Vascular Endothelial Growth Factor Gene Expression in Cardiac Tissue of Diabetic Rats. IRANIAN JOURNAL OF DIABETES AND OBESITY, 12(2), 90-97. SID. https://sid.ir/paper/773583/en

    Vancouver: Copy

    Bakhtiari Fariba, MATIN HOMAEE HASAN, GHAZALIAN FARSHAD. The Effect of Aerobic Training on Tumor Necrosis Factor alpha, Hypoxia-Inducible Factor-1 alpha & Vascular Endothelial Growth Factor Gene Expression in Cardiac Tissue of Diabetic Rats. IRANIAN JOURNAL OF DIABETES AND OBESITY[Internet]. 2020;12(2):90-97. Available from: https://sid.ir/paper/773583/en

    IEEE: Copy

    Fariba Bakhtiari, HASAN MATIN HOMAEE, and FARSHAD GHAZALIAN, “The Effect of Aerobic Training on Tumor Necrosis Factor alpha, Hypoxia-Inducible Factor-1 alpha & Vascular Endothelial Growth Factor Gene Expression in Cardiac Tissue of Diabetic Rats,” IRANIAN JOURNAL OF DIABETES AND OBESITY, vol. 12, no. 2, pp. 90–97, 2020, [Online]. Available: https://sid.ir/paper/773583/en

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