COMPARISON OF THE EFFECTS OF ADDING EPINEPHRINE, MIDAZOLAM AND MIDAZOLAM AND NEOSTIGMINE MIXTURE TO LIDOCAINE IN PATIENTS UNDERGOING TRANSABDOMINAL RESECTION OF PROSTATE

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SAHM ALDINI M.A.; BIGIEZADEH SH.

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Journal: Armaghane Danesh Year:2005 | Volume:10 | Issue:3 (39) Page(s): 1-8

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Title

COMPARISON OF THE EFFECTS OF ADDING EPINEPHRINE, MIDAZOLAM AND MIDAZOLAM AND NEOSTIGMINE MIXTURE TO LIDOCAINE IN PATIENTS UNDERGOING TRANSABDOMINAL RESECTION OF PROSTATE

Author(s)

SAHM ALDINI M.A. | BIGIEZADEH SH. | Issue Writer Certificate

Keywords

MIDAZOLAMQ3

NEOSTIGMINEQ2

SPINAL ANESTHESIAQ2

Abstract

Introduction & Objective: Preemptive treatment of perioperative and postoperative pain is one of the principle roles of anesthesiologists. Regional anesthesia following injection of anesthetic drug has fewer side effects than local or systemic anesthesia and induces longer analgesia with high quality. This research aimed to compare the effects of adding epinephrine, MIDAZOLAM and MIDAZOLAM and NEOSTIGMINE mixture to lidocaine in patients undergoing transabdominal resection of prostate.Materials & Methods: This is a double blind randomized clinical trial performed in Doctor Shareeati Hospital in Fasa. Ninethy candidate patients for elective transabdominal resection of prostate who were classified in class I and II of ASA were categorized randomly in 3 groups. In group one 100 mg lidocaine 5% plus 5 ųg epinephrine, in group two 100 mg lidocaine 5% plus 2 mg MIDAZOLAM and in group three 100 mg lidocaine 5% plus 2mg MIDAZOLAM with 25 ųg NEOSTIGMINE was injected into subarachnoid space and then the duration of painlessness and side effects such as nausea, vomiting, respiratory and drowsiness intraoperation and 24 hour post operation were recorded. Results: The duration of analgesia was 130.2‎±‎11.59 minutes in group one, 321.6‎±30.90 minutes in group two and 1417.8‎±‎53.34 minutes in group three. The incidence of nausea and vomiting in group one was 6.5%, in group two was 6% and in group three was 19.4%. The incidence of drowsiness and respiratory depression in all groups were zero. Conclusion: With co-administration of multiple spinal drugs which act in different sites in pain pathway for reducing pain, we can co administrate 25 mg NEOSTIGMINE with 2mg MIDAZOLAM and spinal lidocaine in order to maintain analgesia for 24 hours in patients. The most likely side effects were nausea and vomiting which could be controlled with antiemetic drugs.

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APA: Copy

SAHM ALDINI, M.A., & BIGIEZADEH, SH.. (2005). COMPARISON OF THE EFFECTS OF ADDING EPINEPHRINE, MIDAZOLAM AND MIDAZOLAM AND NEOSTIGMINE MIXTURE TO LIDOCAINE IN PATIENTS UNDERGOING TRANSABDOMINAL RESECTION OF PROSTATE. ARMAGHAN DANESH, 10(3 (39)), 1-8. SID. https://sid.ir/paper/77467/en

Vancouver: Copy

SAHM ALDINI M.A., BIGIEZADEH SH.. COMPARISON OF THE EFFECTS OF ADDING EPINEPHRINE, MIDAZOLAM AND MIDAZOLAM AND NEOSTIGMINE MIXTURE TO LIDOCAINE IN PATIENTS UNDERGOING TRANSABDOMINAL RESECTION OF PROSTATE. ARMAGHAN DANESH[Internet]. 2005;10(3 (39)):1-8. Available from: https://sid.ir/paper/77467/en

IEEE: Copy

M.A. SAHM ALDINI, and SH. BIGIEZADEH, “COMPARISON OF THE EFFECTS OF ADDING EPINEPHRINE, MIDAZOLAM AND MIDAZOLAM AND NEOSTIGMINE MIXTURE TO LIDOCAINE IN PATIENTS UNDERGOING TRANSABDOMINAL RESECTION OF PROSTATE,” ARMAGHAN DANESH, vol. 10, no. 3 (39), pp. 1–8, 2005, [Online]. Available: https://sid.ir/paper/77467/en

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