Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis

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NAFEA OLA; ABDELALEM AZIZ MOHAMED; SAPTAN FATMA; ABDALLA AHMED; IBRAHIM HEND

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Journal: Asia Pacific Journal of Medical Toxicology Year:2019 | Volume:8 | Issue:3 Page(s): 95-100

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Title

Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis

Author(s)

Keywords

Atropine

Fresh Frozen Plasma

Meta-analysis

Organophosphate

Pralidoxime

Abstract

Background: Organophosphate (OP) poisoning is still a major health concern in both developed and developing countries. The standard treatment approaches of (OP) poisoning are not always available as well so they may show a limited success rate. Fresh Frozen Plasma (FFP) is one of Bio-scavengers that have been suggested as a useful therapy through elimination of free Organophosphates. Therefore, this systematic review and Meta-analysis was conducted to update the present evidence about the efficacy of FFP in management of acute OP-intoxicated patients. Method: A computer literature search of PubMed and Scopus was conducted to identify the relevant randomized controlled trials (RCTs). In addition, a manual search of reference lists of the retrieved articles was conducted. Relevant outcomes were pooled as mean difference (MD) risk ratio (RR) by RevMan version 5. 3 for Windows. Results: Pooled data from 3 RCTs (169 patients) showed that adding FFP to conventional therapy to acutely OP intoxicated patients did not improve clinical outcomes regarding total Atropine (MD = 35. 05, 95% CI = [-41. 14 to 111. 24], P-value = 0. 37) and Pralidoxime dosages (MD =-0. 41, 95% CI = [-2. 34 to 1. 51], P-value = 0. 67), length of hospital stay (MD =-2. 08, 95% CI = [-4. 51 to 0. 35], P-value = 0. 09) and mortality (RR = 0. 42, 95% CI = [0. 14 to 1. 27], P-value = 0. 12). Conclusion: Fresh Frozen Plasma did not provide any additional benefit in acutely-OP intoxicated patients compared to the conventional therapy. The limited number and sizes of the included trials are the most probable cause of such effects.

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APA: Copy

NAFEA, OLA, ABDELALEM AZIZ, MOHAMED, SAPTAN, FATMA, ABDALLA, AHMED, & IBRAHIM, HEND. (2019). Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), 8(3), 95-100. SID. https://sid.ir/paper/775043/en

Vancouver: Copy

NAFEA OLA, ABDELALEM AZIZ MOHAMED, SAPTAN FATMA, ABDALLA AHMED, IBRAHIM HEND. Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT)[Internet]. 2019;8(3):95-100. Available from: https://sid.ir/paper/775043/en

IEEE: Copy

OLA NAFEA, MOHAMED ABDELALEM AZIZ, FATMA SAPTAN, AHMED ABDALLA, and HEND IBRAHIM, “Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis,” ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), vol. 8, no. 3, pp. 95–100, 2019, [Online]. Available: https://sid.ir/paper/775043/en

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