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Title

Comparison of the therapeutic methods (pharmacologic and nonpharmacologic) on prevention of post-ERCP pancreatitis: A systematic review and meta-analysis

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Abstract

 Introduction: Pancreatitis is considered as the well-known and serious complication of endoscopic retrograde cholangiopancreatography (ERCP). Different approaches have been suggested to prevent or reduce this complication. Therefore we aim to investigate them in the current study. Methods: This Systematic review was performed in 2019 using Embase, google scholar, PubMed, and Cochrane library. The eligible investigations and outcomes of interest were selected and extracted by two reviewers. Meta-analysis was done using random or fixed-effect models. I-square statistic test was used for heterogeneity analysis. Results: Totally, 2758 articles were searched. Thereafter duplicated and irrelevant articles were excluded, and six articles were entered into the present study. Six randomized controlled trials (RCTs) were considered eligible with a total participants of 1685. The relative risk of postERCP pancreatitis (PEP) was not significantly different in non-steroidal anti-inflammatory drug (NSAID) and Hydration groups (pooled RR = 1. 19, 95% CI: 0. 40 to 3. 50, P value = 0. 74). The random effect model indicated no significant differences between NSAID and NSAID+Hydration groups regarding the incidence of PEP (pooled risk ratio (RR) = 2. 19, 95% CI: 0. 70 to 6. 88, P value = 0. 17). Conclusion: Using only NSAIDs or in part with Hydration can decrease the PEP risk. Lack of studies comparing different approaches of Prophylaxis in Post-ERCP patients or the reporting of different parameters among the existing studies seriously limited the possibility and quality of meta-analysis.

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    APA: Copy

    SHIRMOHAMMADI, MASOOD, SOMI, MOHAMMAD HOSSEIN, GHOJAZADEH, MORTEZA, Hosseinfard, Hossein, TAHMASEBI, FATEMEH, Sheykhsaran, Elham, & Sadrazar, Amin. (2021). Comparison of the therapeutic methods (pharmacologic and nonpharmacologic) on prevention of post-ERCP pancreatitis: A systematic review and meta-analysis. JOURNAL OF RESEARCH IN CLINICAL MEDICINE, 9(1), 0-0. SID. https://sid.ir/paper/775499/en

    Vancouver: Copy

    SHIRMOHAMMADI MASOOD, SOMI MOHAMMAD HOSSEIN, GHOJAZADEH MORTEZA, Hosseinfard Hossein, TAHMASEBI FATEMEH, Sheykhsaran Elham, Sadrazar Amin. Comparison of the therapeutic methods (pharmacologic and nonpharmacologic) on prevention of post-ERCP pancreatitis: A systematic review and meta-analysis. JOURNAL OF RESEARCH IN CLINICAL MEDICINE[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/775499/en

    IEEE: Copy

    MASOOD SHIRMOHAMMADI, MOHAMMAD HOSSEIN SOMI, MORTEZA GHOJAZADEH, Hossein Hosseinfard, FATEMEH TAHMASEBI, Elham Sheykhsaran, and Amin Sadrazar, “Comparison of the therapeutic methods (pharmacologic and nonpharmacologic) on prevention of post-ERCP pancreatitis: A systematic review and meta-analysis,” JOURNAL OF RESEARCH IN CLINICAL MEDICINE, vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/775499/en

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