PROTECTIVE EFFECTS OF LYCOPENE AND ELLAGIC ACID ON GONADAL TISSUE, MATERNAL NEWBORN RATS INDUCED BY CADMIUMCHLORIDE

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HOSHMAND MOTLAGH K.; JAFARI BARMAK M.; DEHGHAN MANSHADI A.; VAHDATI A.; ZARGAR H.R.; MAHMOUDI R.

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Journal: Armaghane Danesh Year:2015 | Volume:20 | Issue:5 (100) Page(s): 369-380

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Title

PROTECTIVE EFFECTS OF LYCOPENE AND ELLAGIC ACID ON GONADAL TISSUE, MATERNAL NEWBORN RATS INDUCED BY CADMIUMCHLORIDE

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Keywords

CADMIUM CHLORIDEQ2

LYCOPENEQ2

ELLAGIC ACIDQ3

NEONATAL RATQ2

GONADSQ2

Abstract

Background & aim: Cadmium is a toxin which reduces the ability of the reproduction in humans.Different antioxidants damaging effects of toxins are eliminated.The purpose of this study was to investigate the protective effects of LYCOPENE and ELLAGIC ACID induced by CADMIUM CHLORIDE on the gonadal tissue of newborn rats during pregnancy.Methods: In the present experimental study, 30 adult female Wistar rats (180-200 gr) were prepared and maintained in standard conditions. The female rats were used for mating with the male. After observation of vaginal plaque, pregnant rats were randomly divided into 5 groups of 6 rats. Group I (normal): They were given normal saline in 13 days during pregnancy. Group II (Control): CADMIUM CHLORIDE (1.5 mg / kg/ IP) was injected and normal saline was given to them in 13 days of during pregnancy. Group III: CADMIUM CHLORIDE (1.5 mg / kg/ IP) was injected and ELLAGIC ACID (10 mg/kg/orally) in 13 days were injected during pregnancy.Group IV: CADMIUM CHLORIDE (1.5 mg / kg/ IP) was injected and copene acid (20 mg/kg/orally) was injected in 13 days of during pregnancy. Group V: CADMIUM CHLORIDE (1.5 mg / kg/ IP) was injected and ELLAGIC ACID (10 mg/kg/orally) and LYCOPENE acid (20 mg/kg/orally) were injected in 13 days during pregnancy. After postpartum, NEONATAL RATs were anesthetized with ether. Animals were dissected, then the testes and Ovaries were removed and transferred to 10% formalin solution. After tissue processing, tissue sections were prepared and H& E stained. Data were analyzed by SPSS software and ANOVA test.Results: Average number of Sertoli cells, spermatogonia, Leydig, and the number of seminiferous tube in control group were compared to other groups that were treated with LYCOPENE - ELLAGIC ACID and ELLAGIC ACID had been reduced-proves to be significant (P<0.05). Average diameter of seminiferous tube in control group compared to other groups that are treated with LYCOPENE - ELLAGIC ACID and ELLAGIC ACID had been reducedproves but is not significant. Mean primordial follicle diameter and number of primordial of ovary tissue in control group compared to other groups that were treated with LYCOPENE - ELLAGIC ACID and ELLAGIC ACID had been increased-proved to be significant (P<0.05).Conclusion: The results showed that the combined treatment of ELLAGIC ACID and LYCOPENE-ellagic acid may have reduced the toxic effects of CADMIUM CHLORIDE and may have improved the process of replicating the sex cells.

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APA: Copy

HOSHMAND MOTLAGH, K., JAFARI BARMAK, M., DEHGHAN MANSHADI, A., VAHDATI, A., ZARGAR, H.R., & MAHMOUDI, R.. (2015). PROTECTIVE EFFECTS OF LYCOPENE AND ELLAGIC ACID ON GONADAL TISSUE, MATERNAL NEWBORN RATS INDUCED BY CADMIUMCHLORIDE. ARMAGHAN DANESH, 20(5 (100)), 369-380. SID. https://sid.ir/paper/77596/en

Vancouver: Copy

HOSHMAND MOTLAGH K., JAFARI BARMAK M., DEHGHAN MANSHADI A., VAHDATI A., ZARGAR H.R., MAHMOUDI R.. PROTECTIVE EFFECTS OF LYCOPENE AND ELLAGIC ACID ON GONADAL TISSUE, MATERNAL NEWBORN RATS INDUCED BY CADMIUMCHLORIDE. ARMAGHAN DANESH[Internet]. 2015;20(5 (100)):369-380. Available from: https://sid.ir/paper/77596/en

IEEE: Copy

K. HOSHMAND MOTLAGH, M. JAFARI BARMAK, A. DEHGHAN MANSHADI, A. VAHDATI, H.R. ZARGAR, and R. MAHMOUDI, “PROTECTIVE EFFECTS OF LYCOPENE AND ELLAGIC ACID ON GONADAL TISSUE, MATERNAL NEWBORN RATS INDUCED BY CADMIUMCHLORIDE,” ARMAGHAN DANESH, vol. 20, no. 5 (100), pp. 369–380, 2015, [Online]. Available: https://sid.ir/paper/77596/en

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