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Information Journal Paper

Title

Neurotoxin Botulinum Inserts Apoptotic Effects on Certain Cancer Cell Lines Via Neural Niche of Tumors: A Molecular Study

Pages

  190-195

Abstract

 Background: Background: Botulinum toxin A (BtxA) is a powerful neurotoxin reported to be effective as a cancer adjuvant therapy with fewer side effects. Previously we showed the apoptotic effects of BtxA on the GBM cell line (U87-MG). In order to confirm the positive neurotoxicity of BtxA on other cancer cell lines, including SK-OV-3, CHO, MCF-7, and PC-3, the present research has designed. Methods: The cell lines prepared, cultured, and exposed to different concentrations of BtxA for 24 and 48 hours. Using MTT, Annexin V/PI assays and western blotting, cell viability, and Apoptosis studied. Results: Our results showed that different BtxA Botox concentrations led to significant cell death in each cell line in a dose-dependent manner (P < 0. 001) but did not for PC-3 cells. The results of the Annexin V/PI staining indicated that BtxA induced Apoptosis after 24 hours. The 1. 45U, 1. 75U, and 1. 65U of BtxA respectively induced more than 50% Apoptosis in MCF 7, SK-OV-3, and CHO cell lines. The results of caspase 3 showed more protein expression in the treated group compares to the control group. Conclusion: BtxA, as a neurotoxin, can insert therapeutic anti-cancer and apoptotic effects on various types of cancerous cells; further studies need to illuminate the possible mechanisms.

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    APA: Copy

    FARHADI, MONA, Jameie, Melikasadat, Derakhshanmehr, Bahareh, Tahmasebi, Moghadam, SOLEIMANI, MARYAM, & JAMEIE, SEYED BEHNAMEDIN. (2020). Neurotoxin Botulinum Inserts Apoptotic Effects on Certain Cancer Cell Lines Via Neural Niche of Tumors: A Molecular Study. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, 7(4), 190-195. SID. https://sid.ir/paper/776146/en

    Vancouver: Copy

    FARHADI MONA, Jameie Melikasadat, Derakhshanmehr Bahareh, Tahmasebi Moghadam, SOLEIMANI MARYAM, JAMEIE SEYED BEHNAMEDIN. Neurotoxin Botulinum Inserts Apoptotic Effects on Certain Cancer Cell Lines Via Neural Niche of Tumors: A Molecular Study. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL[Internet]. 2020;7(4):190-195. Available from: https://sid.ir/paper/776146/en

    IEEE: Copy

    MONA FARHADI, Melikasadat Jameie, Bahareh Derakhshanmehr, Moghadam Tahmasebi, MARYAM SOLEIMANI, and SEYED BEHNAMEDIN JAMEIE, “Neurotoxin Botulinum Inserts Apoptotic Effects on Certain Cancer Cell Lines Via Neural Niche of Tumors: A Molecular Study,” INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, vol. 7, no. 4, pp. 190–195, 2020, [Online]. Available: https://sid.ir/paper/776146/en

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