Association Study of Recurrent Abortion With Chromosomal Abnormalities and Mutation of Prothrombin Gene in 100 Affected Women in the Northwest of Iran

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RAHMANI SEYED ALI; Amiri Reihaneh; Mosapour Parisa

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Journal: Crescent Journal of Medical and Biological Sciences Year:2020 | Volume:7 | Issue:1 Page(s): 134-137

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Title

Association Study of Recurrent Abortion With Chromosomal Abnormalities and Mutation of Prothrombin Gene in 100 Affected Women in the Northwest of Iran

Author(s)

RAHMANI SEYED ALI | Amiri Reihaneh | Mosapour Parisa | Issue Writer Certificate

Keywords

Chromosomal anomalies

Recurrent miscarriage

Prothrombin gene

Abstract

Objectives: Recurrent miscarriage is defined as two or more abortions happening consecutively within less than the twenty weeks of gestation or when the fetus’ s weight is below 500 g. Numerous factors are involved in Recurrent miscarriages, the most important of which are chromosomal abnormalities and females’ genetic clotting condition, thrombophilia, including Factor II, prothrombin, and mutation. The present study aimed at investigating the relationship between the couples’ chromosomal abnormalities and prothrombin mutation in women with Recurrent miscarriages in the northwest of Iran. Materials and Methods: In the present applied research, 100 couples referring for Recurrent miscarriages were subjected to cytogenetic experiments via using the GTG banding. Deep vein thrombosis tests were also conducted on the women based on the restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. Results: Ten out of 100 studied couples were diagnosed with chromosomal abnormalities. All these abnormalities were of structural type. Out of 100 women subjected to clotting factor II, only one heterozygous case was found while the remaining cases were healthy. The control group subjects (n=100) were also found healthy. No significant difference was evidenced between the control and patient groups. Conclusions: Based on the results, 5% of the studied cases had structural chromosome abnormalities and this was in compliance with the results obtained in the prior research. As regards the prothrombin mutation, only one out of one hundred studied women was heterozygous whereas the remaining subjects were healthy; this is consistent with the results obtained in previous studies.

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APA: Copy

RAHMANI, SEYED ALI, Amiri, Reihaneh, & Mosapour, Parisa. (2020). Association Study of Recurrent Abortion With Chromosomal Abnormalities and Mutation of Prothrombin Gene in 100 Affected Women in the Northwest of Iran. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 7(1), 134-137. SID. https://sid.ir/paper/776243/en

Vancouver: Copy

RAHMANI SEYED ALI, Amiri Reihaneh, Mosapour Parisa. Association Study of Recurrent Abortion With Chromosomal Abnormalities and Mutation of Prothrombin Gene in 100 Affected Women in the Northwest of Iran. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2020;7(1):134-137. Available from: https://sid.ir/paper/776243/en

IEEE: Copy

SEYED ALI RAHMANI, Reihaneh Amiri, and Parisa Mosapour, “Association Study of Recurrent Abortion With Chromosomal Abnormalities and Mutation of Prothrombin Gene in 100 Affected Women in the Northwest of Iran,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 7, no. 1, pp. 134–137, 2020, [Online]. Available: https://sid.ir/paper/776243/en

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