Comparison of the Therapeutic Effects of Salbutamol Nebulize with different Concentrations of Saline on Children with Bronchiolitis

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SOLEIMANI GHOLAMREZA; SHAFIGHI SHAHRI ELHAM; Soleimanzadeh Mousavi Seyed Hossein

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Journal Paper

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Journal: Journal of Pediatric Perspectives Year:2020 | Volume:8 | Issue:9 (81) Page(s): 11939-11944

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Title

Comparison of the Therapeutic Effects of Salbutamol Nebulize with different Concentrations of Saline on Children with Bronchiolitis

Author(s)

SOLEIMANI GHOLAMREZA | SHAFIGHI SHAHRI ELHAM | Soleimanzadeh Mousavi Seyed Hossein | Issue Writer Certificate

Keywords

Bronchiolitis

Children

Salbutamol

Nebulizer

Abstract

Background: Bronchiolitis, which is the most common infection of the lower respiratory tract among infants, is characterized by acute inflammation, edema, increased mucosal production, and bronchospasm. We aimed to investigate the effects of saline usage with different concentrations and Salbutamol on the treatment. Materials and Methods: This double-blind, randomized clinical trial was performed on 180 pediatric patients with four weeks to 24 months old admitted to Ali-Ibn-Aboutaleb Hospital in Zahedan, Iran, during 2017-18 for possible diagnosis of acute Bronchiolitis. Patients were divided into three groups of 60 patients using the permissive block method. The first group received 0. 15 mg of Salbutamol Nebulizer and 5 ml of normal saline 0. 9%, the second group received saline 3%, and the third group received saline 5% at the same dose as the first group. Clinical status, oxygen saturation, respiratory and heart rate, intercostal retraction, dyspnea, wheezing before treatment and every 20 minutes after treatment up to 3 times, and Clinical Bronchiolitis Severity Score (CBSS) were collected. Results: In all three groups, there was an increasing trend in oxygen saturation and a decrease in respiratory rate, heart rate, and CBSS. In the first and third groups, there was a significant difference in CBSS after treatment, but in the second group, it was significant only at 20 and 40 minutes after treatment. The mean days of admission for the second group were lower. Conclusion: It seems that due to its cost-effectiveness, lack of complication and earlier efficacy of 5% hypertonic saline in the treatment of Bronchiolitis, hypertonic saline 5% instead of normal saline 0. 9% is more effective and more cost-beneficial achieved in Bronchiolitis remedy.

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References

Efficacy of 3% hypertonic saline in bronchiolitis: A meta-analysis

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APA: Copy

SOLEIMANI, GHOLAMREZA, SHAFIGHI SHAHRI, ELHAM, & Soleimanzadeh Mousavi, Seyed Hossein. (2020). Comparison of the Therapeutic Effects of Salbutamol Nebulize with different Concentrations of Saline on Children with Bronchiolitis. INTERNATIONAL JOURNAL OF PEDIATRICS, 8(9 (81)), 11939-11944. SID. https://sid.ir/paper/776268/en

Vancouver: Copy

SOLEIMANI GHOLAMREZA, SHAFIGHI SHAHRI ELHAM, Soleimanzadeh Mousavi Seyed Hossein. Comparison of the Therapeutic Effects of Salbutamol Nebulize with different Concentrations of Saline on Children with Bronchiolitis. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2020;8(9 (81)):11939-11944. Available from: https://sid.ir/paper/776268/en

IEEE: Copy

GHOLAMREZA SOLEIMANI, ELHAM SHAFIGHI SHAHRI, and Seyed Hossein Soleimanzadeh Mousavi, “Comparison of the Therapeutic Effects of Salbutamol Nebulize with different Concentrations of Saline on Children with Bronchiolitis,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 8, no. 9 (81), pp. 11939–11944, 2020, [Online]. Available: https://sid.ir/paper/776268/en

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