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Information Journal Paper

Title

Gelatin-hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR): Preparation, assessment of the physicochemical properties and the effect on mesenchymal stem cells

Pages

  25-30

Abstract

 Background. Periodontitis can lead to progressive destruction of periodontal tissues supporting the tooth. Developing biomaterials for tissue engineering has noticeably improved the existing treatment options. The present study investigated the Gelatin-Hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR). Methods. The scaffolds were prepared through electrospinning technique, and then the physicochemical properties and the cytotoxic effects on dental-derived mesenchymal Stem cells were assessed. Results. The Nano-scaffolds were successfully prepared with a mono-dispersed nano-scale diameter (0. 10± 102 nm), negative surface charge (0. 17± 20-mV), and uniform network-shaped morphology. The mesenchymal Stem cells derived from the human dental pulp Stem cells (hDPSC) with GelatinHydroxyapatite nano-fibers showed that the prepared scaffolds had a significant proliferative effect. Besides, the applied method can be used to prepare fiber-based structures via other polymeric materials. Conclusion. The incorporation of different materials to decrease the degradation rate of the fibers can match the speed of tissue regeneration. In this case, the prepared nano-fibers can be applied as a membrane biomaterial.

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    APA: Copy

    SHARIFI, SIMIN, SAMIEI, MOHAMMAD, Dalir Abdolahinia, Elaheh, SHAHI, SHAHRIAR, & MALEKI DIZAJ, SOLMAZ. (2020). Gelatin-hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR): Preparation, assessment of the physicochemical properties and the effect on mesenchymal stem cells. JOURNAL OF ADVANCED PERIODONTOLOGY AND IMPLANT DENTISTRY, 12(1), 25-30. SID. https://sid.ir/paper/776284/en

    Vancouver: Copy

    SHARIFI SIMIN, SAMIEI MOHAMMAD, Dalir Abdolahinia Elaheh, SHAHI SHAHRIAR, MALEKI DIZAJ SOLMAZ. Gelatin-hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR): Preparation, assessment of the physicochemical properties and the effect on mesenchymal stem cells. JOURNAL OF ADVANCED PERIODONTOLOGY AND IMPLANT DENTISTRY[Internet]. 2020;12(1):25-30. Available from: https://sid.ir/paper/776284/en

    IEEE: Copy

    SIMIN SHARIFI, MOHAMMAD SAMIEI, Elaheh Dalir Abdolahinia, SHAHRIAR SHAHI, and SOLMAZ MALEKI DIZAJ, “Gelatin-hydroxyapatite nano-fibers as promising scaffolds for guided tissue regeneration (GTR): Preparation, assessment of the physicochemical properties and the effect on mesenchymal stem cells,” JOURNAL OF ADVANCED PERIODONTOLOGY AND IMPLANT DENTISTRY, vol. 12, no. 1, pp. 25–30, 2020, [Online]. Available: https://sid.ir/paper/776284/en

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