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Information Journal Paper

Title

Usefulness of Serum NT-proBNP in Diagnosis of Generalized Seizures in Egyptian Children

Pages

  11187-11195

Abstract

 Background: Seizures may occur in as many as 1% of Children. The most urgent type of Seizures is generalized tonic-clonic Seizures (GTCS). N-terminal prohormone of brain natriuretic peptide (NT-proBNP) has been considered as a promising biomarker in numerous acute illnesses. We aimed to evaluate usefulness of NT-proBNP for diagnosis of generalized Seizures in Children. Materials and Methods: This prospective case control study was conducted upon 80 Children who were classified into four groups; Group I: included 20 patients with idiopathic generalized epileptic Seizures. Group II: included 20 patients with focal epileptic Seizures. Group III: included 20 patients with febrile Seizures. Group IV: included 20 apparently healthy, age and sex matched Children as a normal control. Complete blood count (CBC), blood chemistries, including random blood glucose, calcium, sodium, C-reactive protein (CRP) level, serum Prolactin and NT-proBNP were performed for all Children. Results: Our results revealed significant increase of both Prolactin and NT-proBNP in generalized epileptic and febrile seizure groups than in focal epileptic and control groups (p< 001). The ROC curve analysis showed NT-proBNP, at a cut-off value of > 384 pg/ml, sensitivity (90 %), and specificity (70. 2%) which was near the results of Prolactin at a cut-off value> 25. 9 ng/ml, and showed sensitivity (95. 1%), and specificity (71. 3%). Conclusion: Based on the results, NT-proBNP increase in generalized Seizures either epileptic or febrile; and may be a promising marker to adjust the diagnosis of it at the emergency setting, when history and clinical presentation are equivocal.

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    Cite

    APA: Copy

    Mahgoob, Mohammed Hashem, & Mohammed Moussa, Mahmoud. (2020). Usefulness of Serum NT-proBNP in Diagnosis of Generalized Seizures in Egyptian Children. INTERNATIONAL JOURNAL OF PEDIATRICS, 8(4 (76)), 11187-11195. SID. https://sid.ir/paper/776954/en

    Vancouver: Copy

    Mahgoob Mohammed Hashem, Mohammed Moussa Mahmoud. Usefulness of Serum NT-proBNP in Diagnosis of Generalized Seizures in Egyptian Children. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2020;8(4 (76)):11187-11195. Available from: https://sid.ir/paper/776954/en

    IEEE: Copy

    Mohammed Hashem Mahgoob, and Mahmoud Mohammed Moussa, “Usefulness of Serum NT-proBNP in Diagnosis of Generalized Seizures in Egyptian Children,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 8, no. 4 (76), pp. 11187–11195, 2020, [Online]. Available: https://sid.ir/paper/776954/en

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