مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Effect of Octopine on Oxidative Stress Indices and Serum Levels of Lipids and Trace Elements in Mice with Breast Cancer

Pages

  13-18

Abstract

 Background and objectives: The aim of this study was to evaluate the effectiveness of Octopine (phytogenic-derivative of arginine) on antioxidant indices, Trace elements and lipid profiles of a mouse model of breast cancer. Methods: In this study, 48 Balb/c mice were divided into six groups: healthy control, cancer control, cancer group receiving 50 mg of Octopine, cancer group receiving 100 mg of Octopine and cancer group receiving 150 mg of Octopine. The Octopine treatment was carried out for three weeks. The 4T1 cell line was used to induce cancer. Fasting blood samples were taken from mice to evaluate lipid profile, copper and zinc levels. Malondialdehyde, superoxide dismutase and glutathione peroxidase activity in breast tumor tissues was evaluated. Data were analyzed by SPSS 18 software using one-way ANOVA and t-test. Results: Octopine had no significant effect on superoxide dismutase and glutathione peroxidase activity in the treatment group compared with the control cancer group. However, it significantly increased total antioxidant capacity and decreased malondialdehyde activities. Furthermore, treatment with Octopine significantly decreased serum zinc, copper, TG, cholesterol and low-density lipoprotein levels but significantly increased high-density lipoprotein compared with the untreated cancer group. Conclusion: Octopine administration is effective in reducing some Oxidative stress indices and improving Trace elements abnormalities and lipid profile in mouse models of breast cancer.

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    Cite

    APA: Copy

    Hakim Elahi, Abdolrasoul, SHARIFI, RASOUL, MAHMOODI, MINOO, & KASSAEE, SEYED MEHRDAD. (2020). Effect of Octopine on Oxidative Stress Indices and Serum Levels of Lipids and Trace Elements in Mice with Breast Cancer. MEDICAL LABORATORY JOURNAL, 14(5), 13-18. SID. https://sid.ir/paper/777306/en

    Vancouver: Copy

    Hakim Elahi Abdolrasoul, SHARIFI RASOUL, MAHMOODI MINOO, KASSAEE SEYED MEHRDAD. Effect of Octopine on Oxidative Stress Indices and Serum Levels of Lipids and Trace Elements in Mice with Breast Cancer. MEDICAL LABORATORY JOURNAL[Internet]. 2020;14(5):13-18. Available from: https://sid.ir/paper/777306/en

    IEEE: Copy

    Abdolrasoul Hakim Elahi, RASOUL SHARIFI, MINOO MAHMOODI, and SEYED MEHRDAD KASSAEE, “Effect of Octopine on Oxidative Stress Indices and Serum Levels of Lipids and Trace Elements in Mice with Breast Cancer,” MEDICAL LABORATORY JOURNAL, vol. 14, no. 5, pp. 13–18, 2020, [Online]. Available: https://sid.ir/paper/777306/en

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