The Effect of Gallic Acid Supplement and Resistance Exercise on the Bio-markers of Liver in Intoxicated Male Rats of Anabolic Steroid

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Ranjbar Kazem; Matin Homaie Hassan; AZARBAYEJANI MOHAMMAD ALI; PIRI MAGHSOUD

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Journal: MEDICAL LABORATORY JOURNAL Year:2020 | Volume:14 | Issue:1 Page(s): 44-49

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Title

The Effect of Gallic Acid Supplement and Resistance Exercise on the Bio-markers of Liver in Intoxicated Male Rats of Anabolic Steroid

Author(s)

Ranjbar Kazem | Matin Homaie Hassan | AZARBAYEJANI MOHAMMAD ALI | PIRI MAGHSOUD | Issue Writer Certificate

Keywords

Anabolic Agents

gallic acid

Resistance Training

Abstract

Background and Objectives: Liver is one of the vital organs of the human body. Antioxidants have been shown to play important roles in reducing liver injuries. The aim of this study was to examine the effects of gallic acid supplementation and resistance exercise on liver damage biomarkers in male rats intoxicated by steroid anabolic. Materials and Methods: Forty-two male Wistar rats were randomly divided into six equal groups: control, sham, steroid anabolic (5 mg/kg), steroid anabolic (5 mg/kg) + gallic acid supplementation (50 mg/kg), steroid anabolic (5 mg/kg) + resistance exercise, and steroid anabolic (5 mg/kg) + gallic acid supplementation (50 mg/kg) + resistance exercise. Except for control and sham groups, all groups received (injection) steroid anabolic at a dose of 5 mg / kg body weight once a week. The resistance exercise protocol was comprised of three weekly exercise sessions by 5 rep/3 set of climbing ladder for eight weeks. Data were analyzed via ANOVA and Tukey's post hoc test at a significance level of P<0. 05. Results: The hepatic enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and bilirubin (total and direct), "In the gallic acid supplementation group (P<0. 01, p<0. 01, p<0. 01, p<0. 02, and p<0. 05, respectively), Resistance Training group (p<0. 02, p<0. 01, p<0. 01, p<0. 01, and p<0. 05, respectively), and the gallic acid supplementation group with resistance exercise (P<0. 02, p<0. 01, p<0. 01, p<0. 01, and p<0. 01, respectively)" were significantly reduced compared to the anabolic steroid group. Conclusions: gallic acid supplementation and resistance exercise significantly reduce liver damage biomarkers. However, the simultaneous use of resistance exercise and gallic acid supplementation has no increasing effects on these biomarkers.

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APA: Copy

Ranjbar, Kazem, Matin Homaie, Hassan, AZARBAYEJANI, MOHAMMAD ALI, & PIRI, MAGHSOUD. (2020). The Effect of Gallic Acid Supplement and Resistance Exercise on the Bio-markers of Liver in Intoxicated Male Rats of Anabolic Steroid. MEDICAL LABORATORY JOURNAL, 14(1), 44-49. SID. https://sid.ir/paper/777592/en

Vancouver: Copy

Ranjbar Kazem, Matin Homaie Hassan, AZARBAYEJANI MOHAMMAD ALI, PIRI MAGHSOUD. The Effect of Gallic Acid Supplement and Resistance Exercise on the Bio-markers of Liver in Intoxicated Male Rats of Anabolic Steroid. MEDICAL LABORATORY JOURNAL[Internet]. 2020;14(1):44-49. Available from: https://sid.ir/paper/777592/en

IEEE: Copy

Kazem Ranjbar, Hassan Matin Homaie, MOHAMMAD ALI AZARBAYEJANI, and MAGHSOUD PIRI, “The Effect of Gallic Acid Supplement and Resistance Exercise on the Bio-markers of Liver in Intoxicated Male Rats of Anabolic Steroid,” MEDICAL LABORATORY JOURNAL, vol. 14, no. 1, pp. 44–49, 2020, [Online]. Available: https://sid.ir/paper/777592/en

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