Anti-Mü llerian Hormone Predictive Levels to Determine The Likelihood of Ovarian Hyper-Response in Infertile Women with Polycystic Ovarian Morphology

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AKBARI SENE AZADEH; ASHRAFI MAHNAZ; Alaghmand Fard Nasim; MOHAMMADI NEDA; Mortezapour Alisaraie Mona; ALIZADEH AHAD

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Journal: International Journal of Fertility & Sterility Year:2021 | Volume:15 | Issue:2 Page(s): 115-122

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Title

Anti-Mü llerian Hormone Predictive Levels to Determine The Likelihood of Ovarian Hyper-Response in Infertile Women with Polycystic Ovarian Morphology

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Keywords

Anti-Müllerian Hormone

Assisted Reproductive Technology

Body Mass Index

Ovarian Hyper-Stimulation Syndrome

Polycystic Ovarian Morphology

Abstract

Background: The objective of this study was to investigate serum levels of anti-Mü llerian hormone (AMH) in normal-ovulatory infertile women with Polycystic Ovarian Morphology (PCOM) and their association with ovarian hyper-response. Materials and Methods: This prospective cohort study was carried out on 100 infertile women with PCOM who were treated with an antagonist/agonist triggered stimulation protocol at Shahid Akbar-Abadi Hospital IVF Centre, Tehran, Iran. Serum AMH levels were measured before starting the Assisted Reproductive Technology (ART) cycle and the ovarian hyper-response was evaluated by retrieved oocyte numbers, ooestradiol levels on the triggering day, and the incidence of Ovarian Hyper-Stimulation Syndrome (OHSS) clinical signs and symptoms. Logistic regression and the area under the curve (AUC) were used to estimate the effects of AMH and the accuracy of the test. Results: Receiver operating characteristic (ROC) curve analysis showed that AMH could significantly predict ovarian hyper-response in PCOM patients (AUC=0. 73). The estimated threshold value was 4. 95 ng/ml, with a specificity of 74. 58% (95% confidence interval [CI]: 50. 85, 93. 22) and sensitivity of 73. 17% (95% CI: 48. 78, 92. 68). Logistic regression results showed a significant interaction between AMH and Body Mass Index (BMI, P=0. 008), which indicated that BMI had a moderation effect. Conclusion: Individualized stimulation protocols for patients with isolated PCOM and AMH greater than 4. 95 ng/ml may significantly reduce the chances of developing OHSS. However, the AMH cut-off values to predict ovarian hyperresponse differ for different BMI categories among PCOM patients; thus, it becomes a more precise predictive marker with increasing BMI.

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APA: Copy

AKBARI SENE, AZADEH, ASHRAFI, MAHNAZ, Alaghmand Fard, Nasim, MOHAMMADI, NEDA, Mortezapour Alisaraie, Mona, & ALIZADEH, AHAD. (2021). Anti-Mü llerian Hormone Predictive Levels to Determine The Likelihood of Ovarian Hyper-Response in Infertile Women with Polycystic Ovarian Morphology. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 15(2), 115-122. SID. https://sid.ir/paper/777823/en

Vancouver: Copy

AKBARI SENE AZADEH, ASHRAFI MAHNAZ, Alaghmand Fard Nasim, MOHAMMADI NEDA, Mortezapour Alisaraie Mona, ALIZADEH AHAD. Anti-Mü llerian Hormone Predictive Levels to Determine The Likelihood of Ovarian Hyper-Response in Infertile Women with Polycystic Ovarian Morphology. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2021;15(2):115-122. Available from: https://sid.ir/paper/777823/en

IEEE: Copy

AZADEH AKBARI SENE, MAHNAZ ASHRAFI, Nasim Alaghmand Fard, NEDA MOHAMMADI, Mona Mortezapour Alisaraie, and AHAD ALIZADEH, “Anti-Mü llerian Hormone Predictive Levels to Determine The Likelihood of Ovarian Hyper-Response in Infertile Women with Polycystic Ovarian Morphology,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 15, no. 2, pp. 115–122, 2021, [Online]. Available: https://sid.ir/paper/777823/en

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